Literature DB >> 18222567

Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents.

Armand Gellis1, Hervé Kovacic, Narimène Boufatah, Patrice Vanelle.   

Abstract

New benzimidazole-4,7-diones substituted at 2-position were synthesized via a microwave-assisted reaction using 2-chloromethyl-1,5,6-trimethyl-1H-benzimidazole-4,7-dione 5b as a key intermediate compound. Their cytotoxicity has been evaluated on colon, breast and lung cancer cell lines. The dimer 17 was shown to possess excellent cytotoxicity comparable to that of mitomycin C.

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Year:  2007        PMID： 18222567     DOI： 10.1016/j.ejmech.2007.11.020

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  13 in total

1.  Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation.

Authors:  R Kenchappa; Yadav D Bodke; Sandeep Telkar; M Aruna Sindhe
Journal:  J Chem Biol       Date:  2016-09-08

2.  Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

Authors:  Jeffery J Newsome; Mary Hassani; Elizabeth Swann; Jane M Bibby; Howard D Beall; Christopher J Moody
Journal:  Bioorg Med Chem       Date:  2013-04-06       Impact factor: 3.641

3.  Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand.

Authors:  Huilu Wu; Tao Sun; Ke Li; Bin Liu; Fan Kou; Fei Jia; Jingkun Yuan; Ying Bai
Journal:  Bioinorg Chem Appl       Date:  2011-06-30       Impact factor: 7.778

4.  Synthesis, Crystal Structure, and Spectra Properties of the Cadmium (II) Complex with Bis(N-allylbenzimidazol-2-ylmethyl)benzylamine.

Authors:  Huilu Wu; Jingkun Yuan; Ying Bai; Fan Kou; Fei Jia; Bin Liu
Journal:  Bioinorg Chem Appl       Date:  2011-10-05       Impact factor: 7.778

5.  2-sec-Butyl-1-(2-hy-droxy-eth-yl)-1H-benzimidazole-5-carboxylic acid.

Authors:  Nurasyikin Hamzah; Nurziana Ngah; Shafida Abd Hamid; Aisyah Saad Abdul Rahim
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-06-02

6.  Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs.

Authors:  Bhookya Shankar; Pochampally Jalapathi; Balabadra Saikrishna; Shaym Perugu; Vijjulatha Manga
Journal:  Chem Cent J       Date:  2018-01-09       Impact factor: 4.215

7.  Crystal structures of pure 3-(4-bromo-2-chloro-phen-yl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one and contaminated with 3-(4-bromo-phen-yl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one.

Authors:  Kanan Wahedy; Bassam Abu Thaher; Dieter Schollmeyer; Ihab Almasri; Rami Morjan; Basem Qeshta; Hans-Peter Deigner
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-08-15

8.  Design and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor.

Authors:  Akbar Mobinikhaledi; Behvar Asghari; Mahsa Jabbarpour
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

9.  Original TDAE strategy using propargylic chloride: rapid access to 1,4-diarylbut-3-ynol derivatives.

Authors:  Manon Roche; Thierry Terme; Patrice Vanelle
Journal:  Molecules       Date:  2013-01-25       Impact factor: 4.411

10.  Synthesis and promising in vitro antiproliferative activity of sulfones of a 5-nitrothiazole series.

Authors:  Anita Cohen; Maxime D Crozet; Pascal Rathelot; Nadine Azas; Patrice Vanelle
Journal:  Molecules       Date:  2012-12-21       Impact factor: 4.411
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