| Literature DB >> 18221732 |
Zhang Li1, Wenwu Liu, Zhimin Kang, Shijun Lv, Cuihong Han, Liu Yun, Xuejun Sun, John H Zhang.
Abstract
Hypoxic ischemic (HI) injury in neonates damages brain tissues. We examined the mechanism of hyperbaric oxygen preconditioning (HBO-PC) in neonatal HI rat model. Seven-day-old rat pups were subjected to left common carotid artery ligation and hypoxia (8% oxygen at 37 degrees C) for 90 min. HBO (100% O(2), 2.5 atmospheres absolute for 2.5 h) were administered by placing pups in a chamber 24 h before HI insult. Brain injury was assessed by the survival rate, 2,3,5-triphenyltetrazolium chloride (TTC), Nissl, TUNEL straining and caspase-3,caspase-9 activities after HI. In HBO preconditioned animals, survival rate was increased, infarct ratio was decreased, and the positive stained TUNEL cells were reduced, accompanied by the suppression of caspase-3 and -9 activities. These results indicate that a single HBO-PC appears to provide brain protection against HI insult via inhibition of neuronal apoptosis pathways.Entities:
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Year: 2007 PMID： 18221732 DOI： 10.1016/j.brainres.2007.12.039
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252