Estimation of dynamically evolving ellipsoids with applications to medical imaging.

The estimation of dynamically evolving ellipsoids from noisy lower-dimensional projections is examined. In particular, this work describes a model-based approach using geometric reconstruction and recursive estimation techniques to obtain a dynamic estimate of left-ventricular ejection fraction from a gated set of planar myocardial perfusion images. The proposed approach differs from current ejection fraction estimation techniques both in the imaging modality used and in the subsequent processing which yields a dynamic ejection fraction estimate. For this work, the left ventricle is modeled as a dynamically evolving three-dimensional (3-D) ellipsoid. The left-ventricular outline observed in the myocardial perfusion images is then modeled as a dynamic, two-dimensional (2-D) ellipsoid, obtained as the projection of the former 3-D ellipsoid. This data is processed in two ways: first, as a 3-D dynamic ellipsoid reconstruction problem; second, each view is considered as a 2-D dynamic ellipse estimation problem and then the 3-D ejection fraction is obtained by combining the effective 2-D ejection fractions of each view. The approximating ellipsoids are reconstructed using a Rauch-Tung-Striebel smoothing filter, which produces an ejection fraction estimate that is more robust to noise since it is based on the entire data set; in contrast, traditional ejection fraction estimates are based only on true frames of data. Further, numerical studies of the sensitivity of this approach to unknown dynamics and projection geometry are presented, providing a rational basis for specifying system parameters. This investigation includes estimation of ejection fraction from both simulated and real data.