BACKGROUND: Prostate diseases in the dog are generally regarded as representative for their human counterparts. We characterized the normal canine prostate in comparison to the normal human prostate. METHODS: Prostates of dogs were examined histomorphologically and by immunohistochemical detection of the markers CK14, HMWCK, CK5, CK18, CK7, UPIII, PSA, and PSMA. RESULTS: Histomorphologically, the canine prostate lacks the human zonal differentiation, has much more prominent acini, while comprising less stromal tissue. In general, the canine prostate epithelium displayed a highly differentiated character, with no cells expressing CK14, minimal amounts of cells expressing HMWCK/CK5 and the vast majority of cells expressing CK18 and PSA. After castration, the prostate epithelium regressed, and the remaining tubules were largely populated by cells showing a ductal phenotype (HMWCK+/CK5+/CK18+/CK7+). CONCLUSIONS: The human and canine prostate are histologically differently organized. The general scheme of cellular differentiation of the prostate epithelium may however be applicable to both species.
BACKGROUND: Prostate diseases in the dog are generally regarded as representative for their human counterparts. We characterized the normal canine prostate in comparison to the normal human prostate. METHODS: Prostates of dogs were examined histomorphologically and by immunohistochemical detection of the markers CK14, HMWCK, CK5, CK18, CK7, UPIII, PSA, and PSMA. RESULTS: Histomorphologically, the canine prostate lacks the human zonal differentiation, has much more prominent acini, while comprising less stromal tissue. In general, the canine prostate epithelium displayed a highly differentiated character, with no cells expressing CK14, minimal amounts of cells expressing HMWCK/CK5 and the vast majority of cells expressing CK18 and PSA. After castration, the prostate epithelium regressed, and the remaining tubules were largely populated by cells showing a ductal phenotype (HMWCK+/CK5+/CK18+/CK7+). CONCLUSIONS: The human and canine prostate are histologically differently organized. The general scheme of cellular differentiation of the prostate epithelium may however be applicable to both species.
Authors: Silvana G P Campos; Bianca F Gonçalves; Wellerson R Scarano; Lara S Corradi; Fernanda C A Santos; Ana M G Custodio; Patricia S L Vilamaior; Rejane M Góes; Sebastião R Taboga Journal: Int J Exp Pathol Date: 2010-10 Impact factor: 1.925
Authors: Eduardo de Paula Nascente; Renée Laufer Amorim; Carlos Eduardo Fonseca-Alves; Veridiana Maria Brianezi Dignani de Moura Journal: Cancers (Basel) Date: 2022-05-31 Impact factor: 6.575
Authors: Hannah Ruetten; Clara Cole; Marlyse Wehber; Kyle A Wegner; Nicholas M Girardi; Nelson T Peterson; Brandon R Scharpf; Michael F Romero; Michael W Wood; Sara A Colopy; Dale E Bjorling; Chad M Vezina Journal: PLoS One Date: 2020-07-29 Impact factor: 3.240
Authors: Toby Ryman-Tubb; Jennifer H Lothion-Roy; Veronika M Metzler; Anna E Harris; Brian D Robinson; Albert A Rizvanov; Jennie N Jeyapalan; Victoria H James; Gary England; Catrin S Rutland; Jenny L Persson; Lukas Kenner; Mark A Rubin; Nigel P Mongan; Simone de Brot Journal: Vet Med Sci Date: 2021-10-10