| Literature DB >> 18207690 |
Andrea Senff-Ribeiro1, Paulo Henrique da Silva, Olga Meiri Chaim, Luiza Helena Gremski, Kátia Sabrina Paludo, Rafael Bertoni da Silveira, Waldemiro Gremski, Oldemir Carlos Mangili, Silvio Sanches Veiga.
Abstract
Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. The mechanisms by which the venom exerts its noxious effects are currently under investigation. The whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5-40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6-7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. The purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years.Entities:
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Year: 2007 PMID： 18207690 DOI： 10.1016/j.biotechadv.2007.12.003
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227