| Literature DB >> 18207412 |
Soumyaditya Mula1, Debashish Banerjee, Birija S Patro, Sayanti Bhattacharya, Atanu Barik, Sandip K Bandyopadhyay, Subrata Chattopadhyay.
Abstract
The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with (1)O(2), as revealed from the rate constant values of (1)O(2) quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating (1)O(2) generated from certain endogenous photosensitizers.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18207412 DOI： 10.1016/j.bmc.2007.12.052
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641