Literature DB >> 18207392

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.

Ahmed Kamal1, N Shankaraiah, V Devaiah, K Laxma Reddy, Aarti Juvekar, Subrata Sen, Nisha Kurian, Surekha Zingde.   

Abstract

1,2,3-Triazole based molecules are useful pharmacophores for several DNA-alkylating and cross-linking agents. A series of A/C8, C/C2 and A/C8-C/C2-linked 1,2,3-triazole-PBD conjugates have been synthesized by employing 'click' chemistry. These molecules have exhibited promising DNA-binding affinity and anticancer activity in selected human cancer cell lines.

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Year:  2007        PMID： 18207392     DOI： 10.1016/j.bmcl.2007.12.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Synthesis and morphological characterization of block copolymers for improved biomaterials.

Authors:  Scott Schricker; Manuel Palacio; B T S Thirumamagal; Bharat Bhushan
Journal:  Ultramicroscopy       Date:  2010-02-23       Impact factor: 2.689

2.  Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR.

Authors:  Lili Ou; Shuang Han; Wenbo Ding; Ping Jia; Bo Yang; Jose L Medina-Franco; Marc A Giulianotti; Jian-Zhong Chen; Yongping Yu
Journal:  Mol Divers       Date:  2011-07-10       Impact factor: 2.943

3.  An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent.

Authors:  Wang Yan; Chen Xiangyu; Li Ya; Wang Yu; Xu Feng
Journal:  Invest New Drugs       Date:  2019-02-11       Impact factor: 3.850

4.  Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition.

Authors:  Kesari Lakshmi Manasa; Sowjanya Thatikonda; Dilep Kumar Sigalapalli; Sowmya Vuppaladadium; Ganthala Parimala Devi; Chandraiah Godugu; Mallika Alvala; Narayana Nagesh; Bathini Nagendra Babu
Journal:  RSC Med Chem       Date:  2020-09-08

5.  Synthesis and structure characterization of new 1,2,4-oxadiazolo[4,5-d]-1,5-benzothiazepines derivatives containing 2-phenyl-1,2,3-triazole through 1,3-dipolar cycloaddition reaction.

Authors:  De-Bao Yang; Fang-Ming Liu; Feng Xu; Chun Yang; Jia-Wei Ye; Song-Wei Shen; Ying-Lei Zhou; Wei Li
Journal:  Mol Divers       Date:  2008-07-15       Impact factor: 2.943

6.  Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors.

Authors:  Shewei Guo; Yingwei Zhen; Mengguo Guo; Longzhou Zhang; Guosheng Zhou
Journal:  Invest New Drugs       Date:  2018-07-18       Impact factor: 3.850

7.  Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives.

Authors:  Zipeng Gong; Yaping Peng; Jie Qiu; Anbai Cao; Guangcheng Wang; Zhiyun Peng
Journal:  Molecules       Date:  2017-09-15       Impact factor: 4.411

8.  Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer.

Authors:  Jun-Xia Zhang; Jiao-Mei Guo; Ting-Ting Zhang; Hong-Jun Lin; Nai-Song Qi; Zhen-Guo Li; Ji-Chun Zhou; Zhen-Zhong Zhang
Journal:  Molecules       Date:  2018-05-28       Impact factor: 4.411

9.  Synthesis of Novel Glycerol-Derived 1,2,3-Triazoles and Evaluation of Their Fungicide, Phytotoxic and Cytotoxic Activities.

Authors:  Adilson Vidal Costa; Marcos Vinicius Lacerda de Oliveira; Roberta Tristão Pinto; Luiza Carvalheira Moreira; Ediellen Mayara Corrêa Gomes; Thammyres de Assis Alves; Patrícia Fontes Pinheiro; Vagner Tebaldi de Queiroz; Larissa Fonseca Andrade Vieira; Robson Ricardo Teixeira; Waldir Cintra de Jesus Júnior
Journal:  Molecules       Date:  2017-10-07       Impact factor: 4.411

10.  The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker.

Authors:  Iwona E Głowacka; Jan Balzarini; Andrzej E Wróblewski
Journal:  Eur J Med Chem       Date:  2013-10-30       Impact factor: 6.514
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