Yue Chen1, Daniel Norton, Dost Ongur. 1. McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA. ychen@mclean.harvard.edu
Abstract
BACKGROUND: Schizophrenia is a brain disorder that spans across biological and behavioral levels. The links between altered neural circuitry and abnormal behaviors are yet to be understood. Visual motion perception has been established in basic neuroscience and may provide an opportunity to link different levels of brain functions in schizophrenia. Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations. METHODS: We applied a psychophysical paradigm to examine center-surround interaction in schizophrenia. Patients (n = 24) and control subjects (n = 33) judged the direction of a moving random dot pattern (RDP, center) with and without the presence of another concentric surrounding RDP (surround). RESULTS: The presence of a moving surround shifted the perceptual judgments of center motion in the opposite direction from the surround in both subject groups but the magnitude of the perceptual shift was significantly larger in patients. The increased perceptual shift was not correlated with psychotic symptoms, which were mild in this patient sample, or antipsychotic medication. CONCLUSIONS: The increased perceptual shift suggests that the putative surround suppression on visual motion perception is abnormally increased in schizophrenia. This result provides perceptual evidence for altered basic inhibitory control of visual motion context in schizophrenia.
BACKGROUND:Schizophrenia is a brain disorder that spans across biological and behavioral levels. The links between altered neural circuitry and abnormal behaviors are yet to be understood. Visual motion perception has been established in basic neuroscience and may provide an opportunity to link different levels of brain functions in schizophrenia. Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations. METHODS: We applied a psychophysical paradigm to examine center-surround interaction in schizophrenia. Patients (n = 24) and control subjects (n = 33) judged the direction of a moving random dot pattern (RDP, center) with and without the presence of another concentric surrounding RDP (surround). RESULTS: The presence of a moving surround shifted the perceptual judgments of center motion in the opposite direction from the surround in both subject groups but the magnitude of the perceptual shift was significantly larger in patients. The increased perceptual shift was not correlated with psychotic symptoms, which were mild in this patient sample, or antipsychotic medication. CONCLUSIONS: The increased perceptual shift suggests that the putative surround suppression on visual motion perception is abnormally increased in schizophrenia. This result provides perceptual evidence for altered basic inhibitory control of visual motion context in schizophrenia.
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Authors: Daniel J Norton; Ryan K McBain; Diego A Pizzagalli; Alice Cronin-Golomb; Yue Chen Journal: Psychiatry Res Date: 2016-04-14 Impact factor: 3.222