Literature DB >> 18205786

Use of chlorhexidine-impregnated patch at pin site to reduce local morbidity: the ChIPPS Pilot Trial.

Stephanie C Wu1, Ryan T Crews, Charles Zelen, James S Wrobel, David G Armstrong.   

Abstract

Pin tract infection is one of the most common complications associated with the use of external fixation. While some studies have identified the potential benefit of chlorhexidine gluconate-impregnated polyurethane dressings to reduce the incidence of catheter-related bloodstream infections, we are unaware of any published studies that evaluate the effectiveness of similar technologies in reducing the risk for external-fixation-related pin tract infections. Therefore, the purpose of this study was to evaluate the effectiveness of chlorhexidine gluconate-impregnated polyurethane dressing in reducing percutaneous-device-related skin colonisation and local infections. In this initial retrospective cohort, data were abstracted for two groups of consecutive patients undergoing surgery involving external fixation at an interdisciplinary foot and ankle surgical unit. All patients received surgical treatment of their foot/ankle pathology along with application of a hybrid external fixator. Twenty patients (45% male, age 54.5 +/- 3.69 years) received chlorhexidine gluconate-impregnated polyurethane dressing and twenty (55% male, age 55.8 +/- 3.22 years) received standard pin care. There was a significantly higher rate of pin tract infection in patients who received standard pin care compared with those who received chlorhexidine gluconate-impregnated polyurethane dressings (25% versus 0%, P = 0.047). There was no significant difference in any of the descriptive study characteristics (age, gender, diabetes and presence of neuropathy). The results of this initial study suggest that chlorhexidine gluconate-impregnated polyurethane dressing may be effective to reduce the incidence of pin tract infections and help decrease morbidity associated with external fixation.

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Year:  2008        PMID: 18205786      PMCID: PMC7951341          DOI: 10.1111/j.1742-481X.2007.00368.x

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  37 in total

1.  Infections in periarticular fractures of the lower extremity treated with tensioned wire hybrid fixators.

Authors:  J J Hutson; G A Zych
Journal:  J Orthop Trauma       Date:  1998 Mar-Apr       Impact factor: 2.512

Review 2.  Static external fixation in the hand and carpus.

Authors:  G M Lourie; R E Lins
Journal:  Hand Clin       Date:  1997-11       Impact factor: 1.907

3.  Value of white blood cell count with differential in the acute diabetic foot infection.

Authors:  D G Armstrong; T A Perales; R T Murff; G W Edelson; J G Welchon
Journal:  J Am Podiatr Med Assoc       Date:  1996-05

4.  Improvement of the bone-pin interface strength in osteoporotic bone with use of hydroxyapatite-coated tapered external-fixation pins. A prospective, randomized clinical study of wrist fractures.

Authors:  A Moroni; C Faldini; S Marchetti; M Manca; V Consoli; S Giannini
Journal:  J Bone Joint Surg Am       Date:  2001-05       Impact factor: 5.284

5.  A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates.

Authors:  J S Garland; C P Alex; C D Mueller; D Otten; C Shivpuri; M C Harris; M Naples; J Pellegrini; R K Buck; T L McAuliffe; D A Goldmann; D G Maki
Journal:  Pediatrics       Date:  2001-06       Impact factor: 7.124

Review 6.  Evidence-based practice for pin site care in injured children.

Authors:  L M Bernardo
Journal:  Orthop Nurs       Date:  2001 Sep-Oct       Impact factor: 0.913

7.  Pin site care in external fixation sodium chloride or chlorhexidine solution as a cleansing agent.

Authors:  Annette W-Dahl; Sören Toksvig-Larsen
Journal:  Arch Orthop Trauma Surg       Date:  2004-08-28       Impact factor: 3.067

8.  Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes.

Authors:  R Aly; H I Maibach
Journal:  Am J Infect Control       Date:  1988-08       Impact factor: 2.918

9.  Comparative evaluation of surgical scrub preparations.

Authors:  A F Peterson; A Rosenberg; S D Alatary
Journal:  Surg Gynecol Obstet       Date:  1978-01

10.  Pin tract infections: silver vs uncoated pins.

Authors:  C A Collinge; G Goll; D Seligson; K J Easley
Journal:  Orthopedics       Date:  1994-05       Impact factor: 1.390

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  7 in total

1.  Development of antibacterial coating on silicone surface via chlorhexidine-loaded nanospheres.

Authors:  Hathaichanok Phuengkham; Norased Nasongkla
Journal:  J Mater Sci Mater Med       Date:  2015-01-29       Impact factor: 3.896

2.  Polymeric multilayers that localize the release of chlorhexidine from biologic wound dressings.

Authors:  Ankit Agarwal; Tyler B Nelson; Patricia R Kierski; Michael J Schurr; Christopher J Murphy; Charles J Czuprynski; Jonathan F McAnulty; Nicholas L Abbott
Journal:  Biomaterials       Date:  2012-07-09       Impact factor: 12.479

3.  Reduction in wound bioburden using a silver-loaded dissolvable microfilm construct.

Authors:  Maggie Herron; Ankit Agarwal; Patricia R Kierski; Diego F Calderon; Leandro B C Teixeira; Michael J Schurr; Christopher J Murphy; Charles J Czuprynski; Jonathan F McAnulty; Nicholas L Abbott
Journal:  Adv Healthc Mater       Date:  2014-02-12       Impact factor: 9.933

4.  Efficacy of 1 % silver sulphadiazine dressings in preventing infection of external fixation pin-tracks: a randomized study.

Authors:  Alfred O Ogbemudia; Anirejuoritse Bafor; Ehimwenma J Ogbemudia; Edwin Edomwonyi
Journal:  Strategies Trauma Limb Reconstr       Date:  2015-08-15

Review 5.  Prevention of pin site infection in external fixation: a review of the literature.

Authors:  Nikolas H Kazmers; Austin T Fragomen; S Robert Rozbruch
Journal:  Strategies Trauma Limb Reconstr       Date:  2016-05-12

Review 6.  Use of Chlorhexidine Preparations in Total Joint Arthroplasty.

Authors:  Jaiben George; Alison K Klika; Carlos A Higuera
Journal:  J Bone Jt Infect       Date:  2017-01-01

7.  Synthesis, characterization, and efficacy of antimicrobial chlorhexidine hexametaphosphate nanoparticles for applications in biomedical materials and consumer products.

Authors:  Michele E Barbour; Sarah E Maddocks; Natalie J Wood; Andrew M Collins
Journal:  Int J Nanomedicine       Date:  2013-09-19
  7 in total

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