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Literature DB >> 18204457

A secreted luciferase for ex vivo monitoring of in vivo processes.

Thomas Wurdinger¹, Christian Badr, Lisa Pike, Ruben de Kleine, Ralph Weissleder, Xandra O Breakefield, Bakhos A Tannous.

Abstract

Luciferases are widely used to monitor biological processes. Here we describe the naturally secreted Gaussia princeps luciferase (Gluc) as a highly sensitive reporter for quantitative assessment of cells in vivo by measuring its concentration in blood. The Gluc blood assay complements in vivo bioluminescence imaging, which has the ability to localize the signal and provides a multifaceted assessment of cell viability, proliferation and location in experimental disease and therapy models.

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Year: 2008 PMID： 18204457 PMCID： PMC2699561 DOI： 10.1038/nmeth.1177

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

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