PURPOSE: In women the relationship between myotonic dystrophy type I and fertility remains controversial. The objective of this study was to evaluate the ovarian reserve, ovarian response to stimulation and oocyte quality in these patients. MATERIALS AND METHODS: We compared 15 myotonic dystrophy type I patients with 39 age matched controls with isolated male factor infertility necessitating ICSI. RESULTS: All parameters of ovarian reserve (day 3 FSH and E2, antral follicle count and delta E2) were significantly better in the controls. Despite having significantly lower doses of gonadotrophin, the control group attained a higher number of retrieved oocyte-cumulus complexes (p < 0.04). Analysis of cytoplasmic and extracytoplasmic dysmorphism did not reveal any difference between the two groups. Fertilisation rate and top grade embryos on day 3 were similar in both groups. CONCLUSION: The present study suggests that though women with myotonic dystrophy type I have a reduced ovarian reserve and respond poorly to controlled ovarian stimulation, there is no impact on oocyte and embryo quality. Hence suggesting that successful ART is feasible with appropriate selection in women with mild myotonic dystrophy.
PURPOSE: In women the relationship between myotonic dystrophy type I and fertility remains controversial. The objective of this study was to evaluate the ovarian reserve, ovarian response to stimulation and oocyte quality in these patients. MATERIALS AND METHODS: We compared 15 myotonic dystrophy type Ipatients with 39 age matched controls with isolated male factor infertility necessitating ICSI. RESULTS: All parameters of ovarian reserve (day 3 FSH and E2, antral follicle count and delta E2) were significantly better in the controls. Despite having significantly lower doses of gonadotrophin, the control group attained a higher number of retrieved oocyte-cumulus complexes (p < 0.04). Analysis of cytoplasmic and extracytoplasmic dysmorphism did not reveal any difference between the two groups. Fertilisation rate and top grade embryos on day 3 were similar in both groups. CONCLUSION: The present study suggests that though women with myotonic dystrophy type I have a reduced ovarian reserve and respond poorly to controlled ovarian stimulation, there is no impact on oocyte and embryo quality. Hence suggesting that successful ART is feasible with appropriate selection in women with mild myotonic dystrophy.
Authors: A C Magee; A E Hughes; A Kidd; A Lopez De Munain; A M Cobo; K Kelly; J Dean; N C Nevin Journal: J Med Genet Date: 2002-03 Impact factor: 6.318
Authors: H G Harley; J D Brook; S A Rundle; S Crow; W Reardon; A J Buckler; P S Harper; D E Housman; D J Shaw Journal: Nature Date: 1992-02-06 Impact factor: 49.962
Authors: Michael D Powell; Gaurishankar Manandhar; Lee Spate; Miriam Sutovsky; Shawn Zimmerman; Shrikesh C Sachdev; Mark Hannink; Randall S Prather; Peter Sutovsky Journal: Proteomics Clin Appl Date: 2010-01-04 Impact factor: 3.494
Authors: Willem Verpoest; Sara Seneca; Marjan De Rademaeker; Karen Sermon; Martine De Rycke; Michel De Vos; Patrick Haentjens; Paul Devroey; Ingeborg Liebaers Journal: J Assist Reprod Genet Date: 2010-03-11 Impact factor: 3.412
Authors: Raquel María Fernández; María Dolores Lozano-Arana; Beatriz Sánchez; Ana Peciña; Juan Carlos García-Lozano; Salud Borrego; Guillermo Antiñolo Journal: Biomed Res Int Date: 2017-11-14 Impact factor: 3.411
Authors: Olesja Parmova; Eva Vlckova; Monika Hulova; Livie Mensova; Igor Crha; Petra Stradalova; Eva Kralickova; Lenka Jurikova; Martina Podborska; Radim Mazanec; Ladislav Dusek; Jiri Jarkovsky; Josef Bednarik; Stanislav Vohanka; Iva Srotova Journal: Medicine (Baltimore) Date: 2020-06-05 Impact factor: 1.817
Authors: Ahmed Gad; José María Sánchez; John A Browne; Lucie Nemcova; Jozef Laurincik; Radek Prochazka; Pat Lonergan Journal: Sci Rep Date: 2020-11-05 Impact factor: 4.379