Literature DB >> 1820270

Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.

P P Bolsaitis1, A S Feitelberg, V Dekermendjian, J F Elliott, A F Sarofim, W G Thilly.   

Abstract

A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH fraction is higher when it is contacted with cells as a liquid extract than when it is supplied as a coating on soot particles. The substrate particles were found to be nonmutagenic. The rate of transfer of mutagens from the surface of particles, combined with the retention time of respirable aerosol particles, are deemed to define their mutagenic potential.

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Year:  1991        PMID： 1820270      PMCID： PMC1568249          DOI： 10.1289/ehp.9196239

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  12 in total

1.  A human cell line sensitive to mutation by particle-borne chemicals.

Authors:  C L Crespi; H L Liber; T D Behymer; R A Hites; W G Thilly
Journal:  Mutat Res       Date:  1985-07       Impact factor: 2.433

2.  Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens.

Authors:  R L Davies; C L Crespi; K Rudo; T R Turner; R Langenbach
Journal:  Carcinogenesis       Date:  1989-05       Impact factor: 4.944

3.  Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism.

Authors:  C L Crespi; W G Thilly
Journal:  Mutat Res       Date:  1984-09       Impact factor: 2.433

4.  Effects of adsorption of benzo[a]pyrene onto carbon black particles on levels of DNA adducts in lungs of rats exposed by inhalation.

Authors:  R K Wolff; J A Bond; J D Sun; R F Henderson; J R Harkema; W C Griffith; J L Mauderly; R O McClellan
Journal:  Toxicol Appl Pharmacol       Date:  1989-02       Impact factor: 4.219

5.  Effects of particulate matter on rates of membrane uptake of polynuclear aromatic hydrocarbons.

Authors:  D R Bevan; S C Riemer; J R Lakowicz
Journal:  J Toxicol Environ Health       Date:  1981 Jul-Aug

6.  Mutagenicity of diesel exhaust particles and oil shale particles dispersed in lecithin surfactant.

Authors:  W E Wallace; M J Keane; C A Hill; J Xu; T M Ong
Journal:  J Toxicol Environ Health       Date:  1987

7.  Transport of a carcinogen, benzo[a]pyrene, from particulates to lipid bilayers: a model for the fate of particle-adsorbed polynuclear aromatic hydrocarbons which are retained in the lungs.

Authors:  J R Lakowicz; D R Bevan; S C Riemer
Journal:  Biochim Biophys Acta       Date:  1980-05-07

8.  A model for the release of adsorbed molecules from the surfaces of airborne particulate matter based on liquid-phase desorption from amorphous carbon blacks.

Authors:  T H Risby; S S Sehnert; L Jiang; B S Dhingra
Journal:  Environ Health Perspect       Date:  1988-04       Impact factor: 9.031

9.  A model for the formation of airborne particulate matter based on the gas-phase adsorption on amorphous carbon blacks.

Authors:  T H Risby; S S Sehnert
Journal:  Environ Health Perspect       Date:  1988-04       Impact factor: 9.031

10.  Chromatographic modeling of the release of particle-adsorbed molecules into synthetic alveolar surfactant.

Authors:  S S Sehnert; T H Risby
Journal:  Environ Health Perspect       Date:  1988-06       Impact factor: 9.031
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