Literature DB >> 18202386

An accurate model for genetic hitchhiking.

Anders Eriksson1, Pontus Fernström, Bernhard Mehlig, Serik Sagitov.   

Abstract

We suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns<10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and direct numerical simulations of a Moran model notable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

Mesh:

Year:  2008        PMID: 18202386      PMCID: PMC2206092          DOI: 10.1534/genetics.107.076018

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  17 in total

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  4 in total

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