Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The involvement of astrocytes and kynurenine pathway in Alzheimer's disease.

Literature DB >> 18201952

The involvement of astrocytes and kynurenine pathway in Alzheimer's disease.

Ka Ka Ting¹, Bruce Brew, Gilles Guillemin.

Abstract

The kynurenine pathway (KP) and several of its neuroactive products, especially quinolinic acid (QUIN), are considered to be involved in the neuropathogenesis of Alzheimer's disease (AD). There is growing evidence suggesting that astrocytes play a critical role in the regulation of the excitotoxicity and inflammatory processes that occur during the evolution of AD. This review focuses on the role of astrocytes through their relation with the KP to the different features associated with AD including cytokine, chemokine and adhesion molecule production, cytoskeletal changes, astrogliosis, excitotoxicity, apoptosis and neurodegeneration.

Entities: Chemical Disease

Mesh：

Substances：
Kynurenine

Year: 2007 PMID： 18201952 DOI： 10.1007/bf03033908

Source DB: PubMed Journal: Neurotox Res ISSN： 1029-8428 Impact factor: 3.911

134 in total

1. Astroglial-induced in vitro angiogenesis: requirements for RNA and protein synthesis.

Authors: J Laterra; G W Goldstein
Journal: J Neurochem Date: 1991-10 Impact factor: 5.372

2. Glial fibrillary acidic protein and beta A4 protein deposits in temporal lobe of aging brain and senile dementia of the Alzheimer type: relation with the cognitive state and with quantitative studies of senile plaques and neurofibrillary tangles.

Authors: M L Harpin; P Delaère; F Javoy-Agid; E Bock; C Jacque; B Delpech; H Villarroya; C Duyckaerts; J J Hauw; N Baumann
Journal: J Neurosci Res Date: 1990-12 Impact factor: 4.164

3. IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment.

Authors: G J Guillemin; S J Kerr; L A Pemberton; D G Smith; G A Smythe; P J Armati; B J Brew
Journal: J Interferon Cytokine Res Date: 2001-12 Impact factor: 2.607

4. Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats.

Authors: Y Takamiya; S Kohsaka; S Toya; M Otani; Y Tsukada
Journal: Brain Res Date: 1988-02-01 Impact factor: 3.252

5. A caspase-3-like protease is involved in NF-kappaB activation induced by stimulation of N-methyl-D-aspartate receptors in rat striatum.

Authors: Z Qin; Y Wang; T N Chasea
Journal: Brain Res Mol Brain Res Date: 2000-09-15

6. Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions.

Authors: J Drejer; O M Larsson; A Schousboe
Journal: Exp Brain Res Date: 1982 Impact factor: 1.972

Review 7. Tryptophan and the immune response.

Authors: John R Moffett; Ma Aryan Namboodiri
Journal: Immunol Cell Biol Date: 2003-08 Impact factor: 5.126

8. Early association of reactive astrocytes with senile plaques in Alzheimer's disease.

Authors: C J Pike; B J Cummings; C W Cotman
Journal: Exp Neurol Date: 1995-04 Impact factor: 5.330

9. Lactate released by Müller glial cells is metabolized by photoreceptors from mammalian retina.

Authors: C L Poitry-Yamate; S Poitry; M Tsacopoulos
Journal: J Neurosci Date: 1995-07 Impact factor: 6.167

10. Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants.

Authors: P N Moynagh; D C Williams; L A O'Neill
Journal: J Immunol Date: 1994-09-15 Impact factor: 5.422

18 in total

Review 1. Inflammation-associated depression: from serotonin to kynurenine.

Authors: Robert Dantzer; Jason C O'Connor; Marcus A Lawson; Keith W Kelley
Journal: Psychoneuroendocrinology Date: 2010-10-30 Impact factor: 4.905

2. The current understanding of overlap between characteristics of HIV-associated neurocognitive disorders and Alzheimer's disease.

Authors: Leah H Rubin; Erin E Sundermann; David J Moore
Journal: J Neurovirol Date: 2019-01-22 Impact factor: 2.643

3. Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease.

Authors: S Duleu; A Mangas; F Sevin; B Veyret; A Bessede; M Geffard
Journal: Int J Alzheimers Dis Date: 2010-03-15

4. Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits.

Authors: Min Wu; Aaron Audet; Jenna Cusic; Drew Seeger; Richard Cochran; Othman Ghribi
Journal: J Neurochem Date: 2009-09-18 Impact factor: 5.372

5. NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade.

Authors: Samer O Abdul-Hay; Jia Luo; Rezene T Ashghodom; Gregory R J Thatcher
Journal: J Neurochem Date: 2009-08-21 Impact factor: 5.372