Literature DB >> 18199905

Incorporating partial shining effects in proton pencil-beam dose calculation.

Yupeng Li1, Xiaodong Zhang, Mingfwu Lii, Narayan Sahoo, Ron X Zhu, Michael Gillin, Radhe Mohan.   

Abstract

A range modulator wheel (RMW) is an essential component in passively scattered proton therapy. We have observed that a proton beam spot may shine on multiple steps of the RMW. Proton dose calculation algorithms normally do not consider the partial shining effect, and thus overestimate the dose at the proximal shoulder of spread-out Bragg peak (SOBP) compared with the measurement. If the SOBP is adjusted to better fit the plateau region, the entrance dose is likely to be underestimated. In this work, we developed an algorithm that can be used to model this effect and to allow for dose calculations that better fit the measured SOBP. First, a set of apparent modulator weights was calculated without considering partial shining. Next, protons spilled from the accelerator reaching the modulator wheel were simplified as a circular spot of uniform intensity. A weight-splitting process was then performed to generate a set of effective modulator weights with the partial shining effect incorporated. The SOBPs of eight options, which are used to label different combinations of proton-beam energy and scattering devices, were calculated with the generated effective weights. Our algorithm fitted the measured SOBP at the proximal and entrance regions much better than the ones without considering partial shining effect for all SOBPs of the eight options. In a prostate patient, we found that dose calculation without considering partial shining effect underestimated the femoral head and skin dose.

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Year:  2008        PMID: 18199905     DOI: 10.1088/0031-9155/53/3/007

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  4 in total

1.  Clinical characterization of a proton beam continuous uniform scanning system with dose layer stacking.

Authors:  J B Farr; A E Mascia; W C Hsi; C E Allgower; F Jesseph; A N Schreuder; M Wolanski; D F Nichiporov; V Anferov
Journal:  Med Phys       Date:  2008-11       Impact factor: 4.071

2.  Uncertainty incorporated beam angle optimization for IMPT treatment planning.

Authors:  Wenhua Cao; Gino J Lim; Andrew Lee; Yupeng Li; Wei Liu; X Ronald Zhu; Xiaodong Zhang
Journal:  Med Phys       Date:  2012-08       Impact factor: 4.071

3.  Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer.

Authors:  Xiaodong Zhang; Kuai-le Zhao; Thomas M Guerrero; Sean E McGuire; Brian Yaremko; Ritsuko Komaki; James D Cox; Zhouguang Hui; Yupeng Li; Wayne D Newhauser; Radhe Mohan; Zhongxing Liao
Journal:  Int J Radiat Oncol Biol Phys       Date:  2008-09-01       Impact factor: 7.038

4.  Commissioning and initial experience with the first clinical gantry-mounted proton therapy system.

Authors:  Tianyu Zhao; Baozhou Sun; Kevin Grantham; Leith Rankine; Bin Cai; Sreekrishna M Goddu; Lakshmi Santanam; Nels Knutson; Tiezhi Zhang; Michael Reilly; Beth Bottani; Jeffrey Bradley; Sasa Mutic; Eric E Klein
Journal:  J Appl Clin Med Phys       Date:  2016-03-08       Impact factor: 2.102

  4 in total

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