OBJECTIVE: To assess the use rate and assisted reproductive technologies (ART) outcome of the cryopreserved semen of cancer patients with an average follow-up of 7 years (range, 2-23 years). DESIGN: Retrospective data analysis. SETTING: University-affiliated andrology and reproduction center. PATIENT(S): Six hundred twenty-nine male cancer patients who were referred for semen cryopreservation between 1983 and 2004. INTERVENTION(S): Review of patient characteristics and ART outcome. MAIN OUTCOME MEASURE(S): Use rate and live births using cryopreserved semen. RESULT(S): A total of 749 semen samples from 557 men were preserved. Ninety-one patients died during follow-up, and another 29 requested disposal. Forty-two patients requested the use of their banked semen. ART data were available for 37 patients. A total of 101 ART cycles (32 IVF, 53 intracytoplasmic sperm injection [ICSIs], nine cryo-ET, and seven intrauterine inseminations [IUIs]) were performed, resulting in, respectively, 8, 16, 2, and 1 pregnancies. Pregnancies rates for IVF and ICSI were significantly higher than those for IUI. CONCLUSION(S): So far, 7.5% of the cancer survivors have used their banked semen, which led to live births in 49% of the couples. Semen cryopreservation is a reliable method to preserve fertility potential and gives couples a reasonable chance of achieving parenthood.
OBJECTIVE: To assess the use rate and assisted reproductive technologies (ART) outcome of the cryopreserved semen of cancerpatients with an average follow-up of 7 years (range, 2-23 years). DESIGN: Retrospective data analysis. SETTING: University-affiliated andrology and reproduction center. PATIENT(S): Six hundred twenty-nine male cancerpatients who were referred for semen cryopreservation between 1983 and 2004. INTERVENTION(S): Review of patient characteristics and ART outcome. MAIN OUTCOME MEASURE(S): Use rate and live births using cryopreserved semen. RESULT(S): A total of 749 semen samples from 557 men were preserved. Ninety-one patients died during follow-up, and another 29 requested disposal. Forty-two patients requested the use of their banked semen. ART data were available for 37 patients. A total of 101 ART cycles (32 IVF, 53 intracytoplasmic sperm injection [ICSIs], nine cryo-ET, and seven intrauterine inseminations [IUIs]) were performed, resulting in, respectively, 8, 16, 2, and 1 pregnancies. Pregnancies rates for IVF and ICSI were significantly higher than those for IUI. CONCLUSION(S): So far, 7.5% of the cancer survivors have used their banked semen, which led to live births in 49% of the couples. Semen cryopreservation is a reliable method to preserve fertility potential and gives couples a reasonable chance of achieving parenthood.
Authors: James F Smith; Pamela Yango; Eran Altman; Shweta Choudhry; Andrea Poelzl; Alberuni M Zamah; Mitchell Rosen; Peter C Klatsky; Nam D Tran Journal: Stem Cells Transl Med Date: 2014-07-18 Impact factor: 6.940
Authors: Helen Gharwan; Catherine Lai; Cliona Grant; Kieron Dunleavy; Seth M Steinberg; Margaret Shovlin; Tito Fojo; Wyndham H Wilson Journal: Leuk Lymphoma Date: 2016-05-17