| Literature DB >> 18190970 |
Lucina Q Uddin1, A M Clare Kelly, Bharat B Biswal, Daniel S Margulies, Zarrar Shehzad, David Shaw, Manely Ghaffari, John Rotrosen, Lenard A Adler, F Xavier Castellanos, Michael P Milham.
Abstract
Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.Entities:
Mesh：
Year: 2007 PMID： 18190970 DOI： 10.1016/j.jneumeth.2007.11.031
Source DB: PubMed Journal: J Neurosci Methods ISSN： 0165-0270 Impact factor: 2.390