| Literature DB >> 18189348 |
Yveline Henchoz1, Davy Guillarme, Serge Rudaz, Jean-Luc Veuthey, Pierre-Alain Carrupt.
Abstract
Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms.Mesh：
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Year: 2008 PMID： 18189348 DOI： 10.1021/jm7014809
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446