AIM: To examine the association between obesity and gastropharyngeal reflux disease (GPRD) as well as gastroesophageal reflux disease (GERD). METHODS: We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dual-probe pH monitoring from July 2003 to December 2006. The association between body mass index (BMI) and parameters about gastroesophageal or gastropharyngeal reflux was examined in univariate and multivariate analyses. RESULTS: A total of 769 patients (307 men and 462 women; mean age 50.7 years) were finally enrolled. Most variables showing gastroesophageal reflux was higher in the obese patients than the patients with normal BMI. There was no difference in all the variables showing gastropharyngeal reflux according to the BMI. After adjustment for age, sex, alcohol intake and smoking, obese patients demonstrated an about 2-fold increase in risk of GERD compared with patients with normal BMI (OR, 1.9; 95 CI, 1.3-2.9), but overweight patients did not demonstrate increased risk of GERD (OR, 1.2; 95 CI, 0.8-1.7). Both obese patients and overweight patients did not demonstrated increased risk of GPRD compared with patients with normal BMI (OR, 1.1; 95 CI, 0.8-1.7; and OR, 0.9; 95 CI, 0.6-1.3, respectively). CONCLUSION: Obesity is not associated with GPRD reflux while it is associated with GERD.
AIM: To examine the association between obesity and gastropharyngeal reflux disease (GPRD) as well as gastroesophageal reflux disease (GERD). METHODS: We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dual-probe pH monitoring from July 2003 to December 2006. The association between body mass index (BMI) and parameters about gastroesophageal or gastropharyngeal reflux was examined in univariate and multivariate analyses. RESULTS: A total of 769 patients (307 men and 462 women; mean age 50.7 years) were finally enrolled. Most variables showing gastroesophageal reflux was higher in the obesepatients than the patients with normal BMI. There was no difference in all the variables showing gastropharyngeal reflux according to the BMI. After adjustment for age, sex, alcohol intake and smoking, obesepatients demonstrated an about 2-fold increase in risk of GERD compared with patients with normal BMI (OR, 1.9; 95 CI, 1.3-2.9), but overweight patients did not demonstrate increased risk of GERD (OR, 1.2; 95 CI, 0.8-1.7). Both obesepatients and overweight patients did not demonstrated increased risk of GPRD compared with patients with normal BMI (OR, 1.1; 95 CI, 0.8-1.7; and OR, 0.9; 95 CI, 0.6-1.3, respectively). CONCLUSION:Obesity is not associated with GPRD reflux while it is associated with GERD.
Authors: S Nandurkar; G R Locke; S Fett; A R Zinsmeister; A J Cameron; N J Talley Journal: Aliment Pharmacol Ther Date: 2004-09-01 Impact factor: 8.171
Authors: Dennis Hong; Yashodhan S Khajanchee; Natasha Pereira; Barbara Lockhart; Emma J Patterson; Lee L Swanstrom Journal: Obes Surg Date: 2004 Jun-Jul Impact factor: 4.129
Authors: D Jaspersen; M Kulig; J Labenz; A Leodolter; T Lind; W Meyer-Sabellek; M Vieth; S N Willich; D Lindner; M Stolte; P Malfertheiner Journal: Aliment Pharmacol Ther Date: 2003-06-15 Impact factor: 8.171
Authors: Regina Promberger; Johannes Lenglinger; Otto Riedl; Gernot Seebacher; Wolf Eilenberg; Johannes Ott; Franz Riegler; Michael Gadenstätter; Christoph Neumayer Journal: BMC Gastroenterol Date: 2013-08-23 Impact factor: 3.067