PURPOSE: To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent. METHODS: One eye of each of 16 Dutch-belted rabbits was injected with intravitreal nanogold; the other eye served as a control. Eight rabbits received a dose of 67 micromol/0.1 mL of nanogold intravitreally into 1 eye; the other 8 rabbits received a dose of 670 micromol/0.1 mL of nanogold intravitreally into 1 eye. Eight rabbits were killed at 1 week, and eight were killed at 1 month; both eyes of each rabbit were enucleated. The eyes were fixed with 2% paraformaldehyde and sectioned for histologic examination. RESULTS: In all injected and control eyes, there was mild vacuolization in the inner plexiform and ganglion cell layers. The retina and retinal pigment epithelium were otherwise histologically normal. CONCLUSION: Intravitreal nanogold at concentrations of 67 micromol/0.1 mL and 670 micromol/0.1 mL showed no signs of retinal or optic nerve toxicity by light microscopy during histologic examination at 1 month.
PURPOSE: To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent. METHODS: One eye of each of 16 Dutch-belted rabbits was injected with intravitreal nanogold; the other eye served as a control. Eight rabbits received a dose of 67 micromol/0.1 mL of nanogold intravitreally into 1 eye; the other 8 rabbits received a dose of 670 micromol/0.1 mL of nanogold intravitreally into 1 eye. Eight rabbits were killed at 1 week, and eight were killed at 1 month; both eyes of each rabbit were enucleated. The eyes were fixed with 2% paraformaldehyde and sectioned for histologic examination. RESULTS: In all injected and control eyes, there was mild vacuolization in the inner plexiform and ganglion cell layers. The retina and retinal pigment epithelium were otherwise histologically normal. CONCLUSION: Intravitreal nanogold at concentrations of 67 micromol/0.1 mL and 670 micromol/0.1 mL showed no signs of retinal or optic nerve toxicity by light microscopy during histologic examination at 1 month.
Authors: T Rajasekar; K Karthika; G Muralitharan; A Maryshamya; S Sabarika; S Anbarasu; K Revathy; N Prasannabalaji; S Kumaran Journal: Braz J Microbiol Date: 2020-05-18 Impact factor: 2.476
Authors: Saloomeh Saati; Rajat N Agrawal; Stan Louie; Gerald J Chader; Mark S Humayun Journal: Graefes Arch Clin Exp Ophthalmol Date: 2009-07-31 Impact factor: 3.117
Authors: Boris A Katsnelson; Larisa I Privalova; Vladimir B Gurvich; Oleg H Makeyev; Vladimir Ya Shur; Yakov B Beikin; Marina P Sutunkova; Ekaterina P Kireyeva; Ilzira A Minigalieva; Nadezhda V Loginova; Marina S Vasilyeva; Artem V Korotkov; Eugene A Shuman; Larisa A Vlasova; Ekaterina V Shishkina; Anastasia E Tyurnina; Roman V Kozin; Irene E Valamina; Svetlana V Pichugova; Ludmila G Tulakina Journal: Int J Mol Sci Date: 2013-01-25 Impact factor: 5.923