Literature DB >> 18184365

Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.

O Wirths1, T A Bayer.   

Abstract

In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.

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Year:  2008        PMID: 18184365     DOI: 10.1111/j.1601-183X.2007.00373.x

Source DB:  PubMed          Journal:  Genes Brain Behav        ISSN: 1601-183X            Impact factor:   3.449


  17 in total

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9.  Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.

Authors:  Ditte Z Christensen; Melanie Huettenrauch; Miso Mitkovski; Laurent Pradier; Oliver Wirths
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