Literature DB >> 1818337

Oligonucleotides as therapeutic agents.

J S Cohen1.   

Abstract

Oligodeoxynucleotides can act as antisense complements to target sequences of mRNAs to selectively regulate gene expression. Chemically modified analogs that are nuclease-resistant enable this antisense strategy to be utilized in practice. Studies with oligodeoxynucleotide analogs in cell free systems, and their cellular uptake will be described. Certain analogs have been found to regulate viral and cellular gene expression. However, some also inhibit in a non-specific manner, that may be traced to their selective inhibition of viral and cellular polymerases. A chemically modified oligodeoxynucleotide analog can be regarded as an informational drug.

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Year:  1991        PMID： 1818337     DOI： 10.1016/0163-7258(91)90009-b

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  10 in total

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Authors:  S Patrick Walton; Ming Wu; Joseph A Gredell; Christina Chan
Journal:  FEBS J       Date:  2010-12       Impact factor: 5.542

2.  CFTR antisense phosphorothioate oligodeoxynucleotides (S-ODns) induce tracheo-bronchial mucin (TBM) mRNA expression in human airway mucosa.

Authors:  M Verma; J Baraniuk; C Blass; M Ali; A Yuta; J Biedlningmaier; E A Davidson
Journal:  Glycoconj J       Date:  1999-01       Impact factor: 2.916

3.  Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver.

Authors:  A Nolting; R K DeLong; M H Fisher; E Wickstrom; G M Pollack; R L Juliano; K L Brouwer
Journal:  Pharm Res       Date:  1997-04       Impact factor: 4.200

Review 4.  Mucin genes: structure, expression and regulation.

Authors:  M Verma; E A Davidson
Journal:  Glycoconj J       Date:  1994-06       Impact factor: 2.916

5.  Synthesis and hybridization properties of oligonucleotides containing 2'-O-modified ribonucleotides.

Authors:  T H Keller; R Häner
Journal:  Nucleic Acids Res       Date:  1993-09-25       Impact factor: 16.971

6.  Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity.

Authors:  G D Jones; E A Lesnik; S R Owens; L M Risen; R T Walker
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

7.  Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

Authors:  K A Higgins; J R Perez; T A Coleman; K Dorshkind; W A McComas; U M Sarmiento; C A Rosen; R Narayanan
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

8.  Sequence-specific interaction of alpha-beta-anomeric double-stranded DNA with the p50 subunit of NF kappa B: application to the decoy approach.

Authors:  H Tanaka; P Vickart; J R Bertrand; B Rayner; F Morvan; J L Imbach; D Paulin; C Malvy
Journal:  Nucleic Acids Res       Date:  1994-08-11       Impact factor: 16.971

9.  BioShuttle mobility in living cells studied with high-resolution FCS & CLSM methodologies.

Authors:  Klaus Braun; Marcel Beining; Manfred Wiessler; Twan Lammers; Rüdiger Pipkorn; Ute Hennrich; Kiyoshi Nokihara; Wolfhard Semmler; Jürgen Debus; Waldemar Waldeck
Journal:  Int J Med Sci       Date:  2012-07-01       Impact factor: 3.738

10.  Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.

Authors:  S K Miroshnichenko; O A Patutina; E A Burakova; B P Chelobanov; A A Fokina; V V Vlassov; S Altman; M A Zenkova; D A Stetsenko
Journal:  Proc Natl Acad Sci U S A       Date:  2019-01-08       Impact factor: 11.205
  10 in total

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