Cağatay Uluçay1, Faik Altintaş, Ender Ugutmen, Burak Beksaç. 1. Department of Orthopedics and Traumatology (Ortopedi ve Travmatoloji Anabilim Dali), Medicine Faculty of Yeditepe University, Istanbul, Turkey. culucay@tnn.net
Abstract
OBJECTIVES: We investigated the effectiveness of arthroscopic debridement followed by viscosupplementation using different hyaluronic acid (HA) products in selected patients with knee osteoarthritis. METHODS: The study included 77 women (mean age 50+/-5 years; range 40 to 60 years) who had mild knee osteoarthritis according to the modified ARA (American Rheumatism Association) criteria and Ahlback classification. All the patients had degenerative meniscal tears. After three weeks from arthroscopic treatment (partial meniscectomy and debridement), the patients were randomly assigned to intra-articular injections of Na-hyaluronate (Orthovisc, n=38), streptococcal HA (Adant, n=21), and Hylan G-F 20 (Synvisc, n=18) given once a week for three weeks. Evaluations were made preoperatively, before and three weeks after injections using a patient satisfaction questionnaire, visual analog scale (VAS), and the WOMAC (Western Ontario and McMaster Universities) osteoarthritis index. RESULTS: All patients had significant improvement following both arthroscopic treatment and viscosupplementation (p<0.0001). Following injections, patient satisfaction (p<0.01), WOMAC and VAS (p<0.0001) scores were significantly improved in the Na-hyaluronate and Hylan G-F 20 groups, whereas the only significant change was in VAS scores in the streptococcal HA group. However, comparison of the three groups did not yield any significant difference with respect to patient satisfaction, WOMAC, and VAS scores (p>0.05). CONCLUSION: Our results suggest that arthroscopic debridement combined with viscosupplementation is an effective treatment option for selected patients with knee osteoarthritis.
RCT Entities:
OBJECTIVES: We investigated the effectiveness of arthroscopic debridement followed by viscosupplementation using different hyaluronic acid (HA) products in selected patients with knee osteoarthritis. METHODS: The study included 77 women (mean age 50+/-5 years; range 40 to 60 years) who had mild knee osteoarthritis according to the modified ARA (American Rheumatism Association) criteria and Ahlback classification. All the patients had degenerative meniscal tears. After three weeks from arthroscopic treatment (partial meniscectomy and debridement), the patients were randomly assigned to intra-articular injections of Na-hyaluronate (Orthovisc, n=38), streptococcal HA (Adant, n=21), and Hylan G-F 20 (Synvisc, n=18) given once a week for three weeks. Evaluations were made preoperatively, before and three weeks after injections using a patient satisfaction questionnaire, visual analog scale (VAS), and the WOMAC (Western Ontario and McMaster Universities) osteoarthritis index. RESULTS: All patients had significant improvement following both arthroscopic treatment and viscosupplementation (p<0.0001). Following injections, patient satisfaction (p<0.01), WOMAC and VAS (p<0.0001) scores were significantly improved in the Na-hyaluronate and Hylan G-F 20 groups, whereas the only significant change was in VAS scores in the streptococcal HA group. However, comparison of the three groups did not yield any significant difference with respect to patient satisfaction, WOMAC, and VAS scores (p>0.05). CONCLUSION: Our results suggest that arthroscopic debridement combined with viscosupplementation is an effective treatment option for selected patients with knee osteoarthritis.
Authors: Ayrton de Paula Pereira Junior; Ricardo Pozzi Fasolin; Felipe Ayusso Correa Sossa; Ozorio de Almeida Lira Neto; Marcelo Schmidt Navarro; Antonio Milani Journal: Rev Bras Ortop Date: 2014-02-12
Authors: Cesáreo Trueba Vasavilbaso; Carlos David Rosas Bello; Erla Medina López; Maria Pilar Coronel Granado; José Mario Navarrete Álvarez; Cesáreo Angel Trueba Davalillo; Félix Isaac Gil Orbezo Journal: Open Access Rheumatol Date: 2017-09-25