| Literature DB >> 18180157 |
Anand Mayasundari1, Antonio M Ferreira, Liwen He, Neeraj Mahindroo, Don Bashford, Naoaki Fujii.
Abstract
This report describes the first small-molecule antagonists that specifically target the ligand-binding pocket of PDZ domains of NHERF1 multi-functional adaptor protein. Comparison of the peptide sequence homology between the native ligand of NHERF1 PDZ domains and an indole-based non-peptide chemical scaffold allowed the design of a small-molecule antagonist of NHERF1 PDZ domains.Entities:
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Year: 2007 PMID： 18180157 DOI： 10.1016/j.bmcl.2007.12.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823