Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts.

Literature DB >> 18177748

GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts.

Abstract

In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-beta-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position -467 to -460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.

Entities: Gene Species

Mesh：

Substances：

Year: 2007 PMID： 18177748 PMCID： PMC2295212 DOI： 10.1016/j.bbagrm.2007.11.012

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

35 in total

Review 1. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

Authors: J D Molkentin
Journal: J Biol Chem Date: 2000-12-15 Impact factor: 5.157

2. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.

Authors: Georges Nemer; Mona Nemer
Journal: Dev Biol Date: 2003-02-01 Impact factor: 3.582

3. Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).

Authors: Taras T Antoniv; Shizuko Tanaka; Bayan Sudan; Sarah De Val; Ke Liu; Lu Wang; Dominic J Wells; George Bou-Gharios; Francesco Ramirez
Journal: J Biol Chem Date: 2005-08-08 Impact factor: 5.157

4. Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program.

Authors: Sashidhar S Nakerakanti; Bagrat Kapanadze; Masaomi Yamasaki; Margaret Markiewicz; Maria Trojanowska
Journal: J Biol Chem Date: 2006-07-06 Impact factor: 5.157

5. Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation.

Authors: W Huang; R Chiquet-Ehrismann; J V Moyano; A Garcia-Pardo; G Orend
Journal: Cancer Res Date: 2001-12-01 Impact factor: 12.701

6. Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways.

Authors: Kim S Midwood; Jean E Schwarzbauer
Journal: Mol Biol Cell Date: 2002-10 Impact factor: 4.138

7. Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction.

Authors: K Imanaka-Yoshida; M Hiroe; T Nishikawa; S Ishiyama; T Shimojo; Y Ohta; T Sakakura; T Yoshida
Journal: Lab Invest Date: 2001-07 Impact factor: 5.662

Review 8. The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling.

Authors: F S Jones; P L Jones
Journal: Dev Dyn Date: 2000-06 Impact factor: 3.780

9. GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts.

Authors: Lu Wang; Shizuko Tanaka; Francesco Ramirez
Journal: Matrix Biol Date: 2005-08 Impact factor: 11.583

10. Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding.

Authors: Michael Eisbacher; Melissa L Holmes; Anthea Newton; Philip J Hogg; Levon M Khachigian; Merlin Crossley; Beng H Chong
Journal: Mol Cell Biol Date: 2003-05 Impact factor: 4.272

10 in total

1. Regulation of tenascin expression in bone.

Authors: Jessica M Morgan; Alice Wong; Clare E Yellowley; Damian C Genetos
Journal: J Cell Biochem Date: 2011-11 Impact factor: 4.429

Review 2. Tenascins and the importance of adhesion modulation.

Authors: Ruth Chiquet-Ehrismann; Richard P Tucker
Journal: Cold Spring Harb Perspect Biol Date: 2011-05-01 Impact factor: 10.005

3. Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension.

Authors: Angela Ghatnekar; Izabela Chrobak; Charlie Reese; Lukasz Stawski; Francesca Seta; Elaine Wirrig; Jesus Paez-Cortez; Margaret Markiewicz; Yoshihide Asano; Russell Harley; Richard Silver; Carol Feghali-Bostwick; Maria Trojanowska
Journal: Am J Pathol Date: 2013-04-11 Impact factor: 4.307

9. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.

Authors: Marie M Lockhart; Elaine E Wirrig; Aimee L Phelps; Angela V Ghatnekar; Jeremy L Barth; Russell A Norris; Andy Wessels
Journal: PLoS One Date: 2013-02-26 Impact factor: 3.240

Review 10. Tenascin-C: Form versus function.

Authors: Sean P Giblin; Kim S Midwood
Journal: Cell Adh Migr Date: 2015 Impact factor: 3.405