BACKGROUND: Evidence that high-protein diets are an effective strategy for the maintenance of long-term weight loss is limited. OBJECTIVE: The objective was to determine the efficacy of a higher protein intake on the maintenance of weight loss after 64 wk of follow-up. DESIGN:Seventy-nine healthy women with a mean (+/-SD) age of 49+/-9 y and a body mass index (in kg/m2) of 32.8+/-3.5 completed an intensive 12-wk weight-loss program and 52 wk of follow-up to compare the effects on weight-loss maintenance of a high-protein (HP) diet (34% of energy) or a high-carbohydrate (HC) diet (64% of energy). RESULTS:Mean (+/-SD) weight loss was not significantly different between groups: (HP: 4.6+/-5.5 kg; HC: 4.4+/-6.1 kg). Protein intake (g) from dietary records at 64 wk was directly related to weight loss (P<0.0001), accounting for 15% of the variance. Protein intake as a percentage of energy was also related to weight change (P=0.003), accounting for 10% of the variance. In the upper tertile (88 g protein/d), weight loss was 6.5+/-7.5 and 3.4+/-4.4 kg (P=0.03) in the 2 lower tertiles, respectively. This difference did not translate to a difference in central fat loss between groups. Lipids, glucose, insulin, C-reactive protein, and homocysteine all improved with weight loss and were not significantly different between groups. HDL cholesterol rose by 20%. Higher serum vitamin B-12 was observed in the HP group, and folate concentrations were not significantly different between groups. CONCLUSIONS: A reported higher protein intake appears to confer some weight-loss benefit. Cardiovascular disease risk factors, biomarkers of disease, and serum vitamins and minerals improved with no differences between groups.
RCT Entities:
BACKGROUND: Evidence that high-protein diets are an effective strategy for the maintenance of long-term weight loss is limited. OBJECTIVE: The objective was to determine the efficacy of a higher protein intake on the maintenance of weight loss after 64 wk of follow-up. DESIGN: Seventy-nine healthy women with a mean (+/-SD) age of 49+/-9 y and a body mass index (in kg/m2) of 32.8+/-3.5 completed an intensive 12-wk weight-loss program and 52 wk of follow-up to compare the effects on weight-loss maintenance of a high-protein (HP) diet (34% of energy) or a high-carbohydrate (HC) diet (64% of energy). RESULTS: Mean (+/-SD) weight loss was not significantly different between groups: (HP: 4.6+/-5.5 kg; HC: 4.4+/-6.1 kg). Protein intake (g) from dietary records at 64 wk was directly related to weight loss (P<0.0001), accounting for 15% of the variance. Protein intake as a percentage of energy was also related to weight change (P=0.003), accounting for 10% of the variance. In the upper tertile (88 g protein/d), weight loss was 6.5+/-7.5 and 3.4+/-4.4 kg (P=0.03) in the 2 lower tertiles, respectively. This difference did not translate to a difference in central fat loss between groups. Lipids, glucose, insulin, C-reactive protein, and homocysteine all improved with weight loss and were not significantly different between groups. HDL cholesterol rose by 20%. Higher serum vitamin B-12 was observed in the HP group, and folate concentrations were not significantly different between groups. CONCLUSIONS: A reported higher protein intake appears to confer some weight-loss benefit. Cardiovascular disease risk factors, biomarkers of disease, and serum vitamins and minerals improved with no differences between groups.
Authors: Kênia M B de Carvalho; Nathalia Pizato; Patrícia B Botelho; Eliane S Dutra; Vivian S S Gonçalves Journal: Eur J Nutr Date: 2020-07-10 Impact factor: 5.614
Authors: E M P Backx; M Tieland; K J Borgonjen-van den Berg; P R Claessen; L J C van Loon; L C P G M de Groot Journal: Int J Obes (Lond) Date: 2015-10-16 Impact factor: 5.095
Authors: Deeptha Sukumar; Hasina Ambia-Sobhan; Robert Zurfluh; Yvette Schlussel; Theodore J Stahl; Chris L Gordon; Sue A Shapses Journal: J Bone Miner Res Date: 2011-06 Impact factor: 6.741
Authors: Ann G Liu; Renee S Puyau; Hongmei Han; William D Johnson; Frank L Greenway; Nikhil V Dhurandhar Journal: J Am Coll Nutr Date: 2015-03-06 Impact factor: 3.169
Authors: Catherine M Champagne; Stephanie T Broyles; Laura D Moran; Katherine C Cash; Erma J Levy; Pao-Hwa Lin; Bryan C Batch; Lillian F Lien; Kristine L Funk; Arlene Dalcin; Catherine Loria; Valerie H Myers Journal: J Am Diet Assoc Date: 2011-12
Authors: Margriet A B Veldhorst; Arie G Nieuwenhuizen; Ananda Hochstenbach-Waelen; Klaas R Westerterp; Marielle P K J Engelen; Robert-Jan M Brummer; Nicolaas E P Deutz; Margriet S Westerterp-Plantenga Journal: Eur J Nutr Date: 2009-01-13 Impact factor: 5.614