BACKGROUND: Obsessive-compulsive disorder (OCD) may be related to a dysfunction in frontostriatal pathways mediating inhibitory control. However, no functional magnetic resonance imaging (fMRI) study has tested this in children. AIMS: To test whether adolescents with OCD in partial remission would show abnormal frontostriatal brain activation during tasks of inhibition. METHOD: Event-related fMRI was used to compare brain activation in 10 adolescent boys with OCD with that of 9 matched controls during three different tasks of inhibitory control. RESULTS: During a 'stop' task, participants with OCD showed reduced activation in right orbitofrontal cortex, thalamus and basal ganglia; inhibition failure elicited mesial frontal underactivation. Task switching and interference inhibition were associated with attenuated activation in frontal, temporoparietal and cerebellar regions. CONCLUSIONS: These preliminary findings support the hypothesis that paediatric OCD is characterised by a dysregulation of frontostriatothalamic brain regions necessary for motor inhibition, and also demonstrate dysfunction of temporoparietal and frontocerebellar attention networks during more cognitive forms of inhibition.
BACKGROUND:Obsessive-compulsive disorder (OCD) may be related to a dysfunction in frontostriatal pathways mediating inhibitory control. However, no functional magnetic resonance imaging (fMRI) study has tested this in children. AIMS: To test whether adolescents with OCD in partial remission would show abnormal frontostriatal brain activation during tasks of inhibition. METHOD: Event-related fMRI was used to compare brain activation in 10 adolescent boys with OCD with that of 9 matched controls during three different tasks of inhibitory control. RESULTS: During a 'stop' task, participants with OCD showed reduced activation in right orbitofrontal cortex, thalamus and basal ganglia; inhibition failure elicited mesial frontal underactivation. Task switching and interference inhibition were associated with attenuated activation in frontal, temporoparietal and cerebellar regions. CONCLUSIONS: These preliminary findings support the hypothesis that paediatric OCD is characterised by a dysregulation of frontostriatothalamic brain regions necessary for motor inhibition, and also demonstrate dysfunction of temporoparietal and frontocerebellar attention networks during more cognitive forms of inhibition.
Authors: Margaret A Richter; Danilo R de Jesus; Sylco Hoppenbrouwers; Melissa Daigle; Jasna Deluce; Lakshmi N Ravindran; Paul B Fitzgerald; Zafiris J Daskalakis Journal: Neuropsychopharmacology Date: 2011-12-14 Impact factor: 7.853
Authors: Jennifer C Britton; Scott L Rauch; Isabelle M Rosso; William D S Killgore; Lauren M Price; Jennifer Ragan; Anne Chosak; Dianne M Hezel; Daniel S Pine; Ellen Leibenluft; David L Pauls; Michael A Jenike; S Evelyn Stewart Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-06-29 Impact factor: 8.829
Authors: Kate Dimond Fitzgerald; Yanni Liu; Timothy D Johnson; Jason S Moser; Rachel Marsh; Gregory L Hanna; Stephan F Taylor Journal: J Am Acad Child Adolesc Psychiatry Date: 2018-04-21 Impact factor: 8.829
Authors: Katya Rubia; Ana Cubillo; Anna B Smith; James Woolley; Isobel Heyman; Michael J Brammer Journal: Hum Brain Mapp Date: 2010-02 Impact factor: 5.038