Literature DB >> 18172208

Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release.

T Kuner1, Y Li, K R Gee, L F Bonewald, G J Augustine.   

Abstract

The time at which the N-ethylmaleimide-sensitive factor (NSF) acts during synaptic vesicle (SV) trafficking was identified by time-controlled perturbation of NSF function with a photoactivatable inhibitory peptide. Photolysis of this caged peptide in the squid giant presynaptic terminal caused an abrupt (0.2 s) slowing of the kinetics of the postsynaptic current (PSC) and a more gradual (2-3 s) reduction in PSC amplitude. Based on the rapid rate of these inhibitory effects relative to the speed of SV recycling, we conclude that NSF functions in reactions that immediately precede neurotransmitter release. Our results indicate the locus of SNARE protein recycling in presynaptic terminals and reveal NSF as a potential target for rapid regulation of transmitter release.

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Year:  2008        PMID： 18172208      PMCID： PMC2224215          DOI： 10.1073/pnas.0707197105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  69 in total

1.  Early requirement for alpha-SNAP and NSF in the secretory cascade in chromaffin cells.

Authors:  T Xu; U Ashery; R D Burgoyne; E Neher
Journal:  EMBO J       Date:  1999-06-15       Impact factor: 11.598

2.  Cytosolic ATPases, p97 and NSF, are sufficient to mediate rapid membrane fusion.

Authors:  M Otter-Nilsson; R Hendriks; E I Pecheur-Huet; D Hoekstra; T Nilsson
Journal:  EMBO J       Date:  1999-04-15       Impact factor: 11.598

3.  Defining the functions of trans-SNARE pairs.

Authors:  C Ungermann; K Sato; W Wickner
Journal:  Nature       Date:  1998-12-10       Impact factor: 49.962

4.  Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles.

Authors:  H Otto; P I Hanson; R Jahn
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

5.  Homotypic vacuolar fusion mediated by t- and v-SNAREs.

Authors:  B J Nichols; C Ungermann; H R Pelham; W T Wickner; A Haas
Journal:  Nature       Date:  1997-05-08       Impact factor: 49.962

6.  A critical role for N-ethylmaleimide-sensitive fusion protein (NSF) in platelet granule secretion.

Authors:  J Polgár; G L Reed
Journal:  Blood       Date:  1999-08-15       Impact factor: 22.113

7.  N-Ethylmaleimide-sensitive factor acts at a prefusion ATP-dependent step in Ca2+-activated exocytosis.

Authors:  A Banerjee; V A Barry; B R DasGupta; T F Martin
Journal:  J Biol Chem       Date:  1996-08-23       Impact factor: 5.157

8.  A possible predocking attachment site for N-ethylmaleimide-sensitive fusion protein. Insights from in vitro endosome fusion.

Authors:  M I Colombo; M Taddese; S W Whiteheart; P D Stahl
Journal:  J Biol Chem       Date:  1996-08-02       Impact factor: 5.157

9.  NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.

Authors:  L A Tolar; L Pallanck
Journal:  J Neurosci       Date:  1998-12-15       Impact factor: 6.167

10.  Association of the fusion protein NSF with clathrin-coated vesicle membranes.

Authors:  G J Steel; M Tagaya; P G Woodman
Journal:  EMBO J       Date:  1996-02-15       Impact factor: 11.598
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  14 in total

1.  Identification of phosphoproteins associated with human neutrophil granules following chemotactic peptide stimulation.

Authors:  Gregory C Luerman; David W Powell; Silvia M Uriarte; Timothy D Cummins; Michael L Merchant; Richard A Ward; Kenneth R McLeish
Journal:  Mol Cell Proteomics       Date:  2010-11-19       Impact factor: 5.911

2.  Vesicle priming in a SNAP.

Authors:  Martin Müller; Graeme W Davis
Journal:  Neuron       Date:  2010-11-04       Impact factor: 17.173

Review 3.  Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF).

Authors:  Chunxia Zhao; Everett C Smith; Sidney W Whiteheart
Journal:  Biochim Biophys Acta       Date:  2011-06-13

4.  The role of mitochondrially derived ATP in synaptic vesicle recycling.

Authors:  Divya Pathak; Lauren Y Shields; Bryce A Mendelsohn; Dominik Haddad; Wei Lin; Akos A Gerencser; Hwajin Kim; Martin D Brand; Robert H Edwards; Ken Nakamura
Journal:  J Biol Chem       Date:  2015-06-30       Impact factor: 5.157

Review 5.  Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

Authors:  Hsien-Ming Lee; Daniel R Larson; David S Lawrence
Journal:  ACS Chem Biol       Date:  2009-06-19       Impact factor: 5.100

Review 6.  Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval.

Authors:  Stephen M Smith; Robert Renden; Henrique von Gersdorff
Journal:  Trends Neurosci       Date:  2008-09-24       Impact factor: 13.837

7.  Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.

Authors:  Fumiko Kawasaki; Richard W Ordway
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-11       Impact factor: 11.205

Review 8.  New photochemical tools for controlling neuronal activity.

Authors:  Richard H Kramer; Doris L Fortin; Dirk Trauner
Journal:  Curr Opin Neurobiol       Date:  2009-10-12       Impact factor: 6.627

9.  Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?

Authors:  Peng Huang; Chunxia Zhao; Chongguang Chen; Sidney W Whiteheart; Lee-Yuan Liu-Chen
Journal:  Handb Exp Pharmacol       Date:  2022

10.  Cortical Granule Exocytosis Is Mediated by Alpha-SNAP and N-Ethilmaleimide Sensitive Factor in Mouse Oocytes.

Authors:  Matilde de Paola; Oscar Daniel Bello; Marcela Alejandra Michaut
Journal:  PLoS One       Date:  2015-08-12       Impact factor: 3.240
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