CONTEXT: Vertebral fractures are the most common osteoporotic fracture. Women with low bone mineral density (BMD) and prevalent vertebral fractures have a greater risk of incident vertebral fractures over the short-term, but their absolute risk of vertebral fracture over the long-term is uncertain. OBJECTIVE: To examine the absolute risk of incident vertebral fracture by BMD and prevalent vertebral fracture status over 15 years. DESIGN, SETTING, AND PARTICIPANTS: A total of 9704 white women were recruited at 4 US clinical centers and enrolled in the Study of Osteoporotic Fractures, a longitudinal cohort study. Of these, 2680 attended a clinic visit an average of 14.9 years after baseline; mean age of 68.8 years at entry and 83.8 years at follow-up. Mean Outcome Measure Incident vertebral fractures identified from lateral spinal radiographs defined as a decrease of at least 20% and 4 mm at any vertebral level. Prevalent vertebral fractures were identified on the baseline radiographs using vertebral morphometry. Bone mineral density was measured at the total hip and lumbar spine using dual-energy x-ray absorptiometry. RESULTS: Of the 2680 women, 487 (18.2%) had an incident vertebral fracture including 163 of the 394 (41.4%) with a prevalent vertebral fracture at baseline and 324 of the 2286 (14.2%) without a prevalent vertebral fracture at baseline (odds ratio, 4.21; 95% confidence interval, 3.33-5.34). Low BMD was associated with an increased risk of incident vertebral fracture (odds ratio per 1 SD decrease in total hip BMD, 1.78 [95% confidence interval, 1.58-2.00]). The absolute risk of vertebral fracture ranged from 56% among women with total hip BMD T score of -2.5 or less and a prevalent vertebral fracture to 9% in women with normal BMD and no prevalent vertebral fracture. CONCLUSIONS: Low BMD and prevalent vertebral fractures are independently related to new vertebral fractures over 15 years of follow-up. Women with a prevalent vertebral fracture have a substantially increased absolute risk of an incident fracture, especially if they have osteoporosis diagnosed by BMD.
CONTEXT: Vertebral fractures are the most common osteoporotic fracture. Women with low bone mineral density (BMD) and prevalent vertebral fractures have a greater risk of incident vertebral fractures over the short-term, but their absolute risk of vertebral fracture over the long-term is uncertain. OBJECTIVE: To examine the absolute risk of incident vertebral fracture by BMD and prevalent vertebral fracture status over 15 years. DESIGN, SETTING, AND PARTICIPANTS: A total of 9704 white women were recruited at 4 US clinical centers and enrolled in the Study of Osteoporotic Fractures, a longitudinal cohort study. Of these, 2680 attended a clinic visit an average of 14.9 years after baseline; mean age of 68.8 years at entry and 83.8 years at follow-up. Mean Outcome Measure Incident vertebral fractures identified from lateral spinal radiographs defined as a decrease of at least 20% and 4 mm at any vertebral level. Prevalent vertebral fractures were identified on the baseline radiographs using vertebral morphometry. Bone mineral density was measured at the total hip and lumbar spine using dual-energy x-ray absorptiometry. RESULTS: Of the 2680 women, 487 (18.2%) had an incident vertebral fracture including 163 of the 394 (41.4%) with a prevalent vertebral fracture at baseline and 324 of the 2286 (14.2%) without a prevalent vertebral fracture at baseline (odds ratio, 4.21; 95% confidence interval, 3.33-5.34). Low BMD was associated with an increased risk of incident vertebral fracture (odds ratio per 1 SD decrease in total hip BMD, 1.78 [95% confidence interval, 1.58-2.00]). The absolute risk of vertebral fracture ranged from 56% among women with total hip BMD T score of -2.5 or less and a prevalent vertebral fractureto 9% in women with normal BMD and no prevalent vertebral fracture. CONCLUSIONS: Low BMD and prevalent vertebral fractures are independently related to new vertebral fractures over 15 years of follow-up. Women with a prevalent vertebral fracture have a substantially increased absolute risk of an incident fracture, especially if they have osteoporosis diagnosed by BMD.
Authors: Elizabeth J Samelson; Blaine A Christiansen; Serkalem Demissie; Kerry E Broe; Qiong Louie-Gao; L Adrienne Cupples; Benjamin J Roberts; Rajaram Manoharam; John D'Agostino; Thomas Lang; Douglas P Kiel; Mary L Bouxsein Journal: J Bone Miner Res Date: 2012-03 Impact factor: 6.741
Authors: Dennis M Black; Jane A Cauley; Rachel Wagman; Kristine Ensrud; Howard A Fink; Teresa A Hillier; Li-Yung Lui; Steven R Cummings; John T Schousboe; Nicola Napoli Journal: J Bone Miner Res Date: 2017-07-18 Impact factor: 6.741
Authors: WanWan Xu; Subashan Perera; Donna Medich; Gail Fiorito; Julie Wagner; Loretta K Berger; Susan L Greenspan Journal: Bone Date: 2010-09-24 Impact factor: 4.398
Authors: Sara Guerri; Daniele Mercatelli; Maria Pilar Aparisi Gómez; Alessandro Napoli; Giuseppe Battista; Giuseppe Guglielmi; Alberto Bazzocchi Journal: Quant Imaging Med Surg Date: 2018-02
Authors: D S Domiciano; L G Machado; J B Lopes; C P Figueiredo; V F Caparbo; L Takayama; R M Oliveira; P R Menezes; R M R Pereira Journal: Osteoporos Int Date: 2014-08-05 Impact factor: 4.507