Jun Chen1, Jin Yu2, Qiang He3, Xiong Zhao3, Hongxun Sang3, Wei Lei3, Zixiang Wu3, Jingyuan Chen4. 1. Department of Occupational & Environmental Health and The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China ; Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China. 2. Department of Cardiovascular Medicine, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China. 3. Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China. 4. Department of Occupational & Environmental Health and The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Xijing Hospital, Fourth Military Medical University 169 Changle West Road, Xi'an 710032, China.
Abstract
PURPOSE: The aim of this study is to determine the feasibility and effectiveness of a novel injectable Porous Surface Modified Bioactive Bone Cement (PSMBBC) for vertebroplasty of aiding osteoporotic vertebrae in an osteoporosis model. METHODS: 72 osteoporosis rabbits were randomly divided into three groups: the Polymethyl Methacrylate (PMMA) group, the PSMBBC group and the control group. PMMA and PSMBBC were administrated to osteoporotic vertebrae in vertebroplasty, respectively. The animals were sacrificed at 1w, 4w, 12w after the procedure. Micro-CT analysis, biomechanical tests and histological analysis were performed at each time point. RESULTS: From 4 to 12 weeks after the implantation of bone cements, the bone volume fraction (BV/TV) of the PSMBBC group increased from 28.27 ± 1.69% to 38.43 ± 1.34%. However, the BV/TV of the PMMA group showed no significant difference after the implantation. At 4 weeks, direct contact between the bone and the bone cement was observed in the PSMBBC group. At 12 weeks, it was discovered that new intact bone trabecular was formed in PSMBBC group. Furthermore, the maximum compressive strength values of the PSMBBC group were significantly higher than those of the control group at each time point after implantation. CONCLUSIONS: In summary, this study was the first investigation to evaluate the potential application of PSMBBC for vertebroplasty. RESULTS demonstrated its beneficial effects on the trabecular ingrowth of new bone and bone mineral density increase. With further validation, PSMBBC can become a valuable biomaterial for aiding osteoporotic vertebrae and usable bone cement applied in vertebroplasty.
PURPOSE: The aim of this study is to determine the feasibility and effectiveness of a novel injectable Porous Surface Modified Bioactive Bone Cement (PSMBBC) for vertebroplasty of aiding osteoporotic vertebrae in an osteoporosis model. METHODS: 72 osteoporosis rabbits were randomly divided into three groups: the Polymethyl Methacrylate (PMMA) group, the PSMBBC group and the control group. PMMA and PSMBBC were administrated to osteoporotic vertebrae in vertebroplasty, respectively. The animals were sacrificed at 1w, 4w, 12w after the procedure. Micro-CT analysis, biomechanical tests and histological analysis were performed at each time point. RESULTS: From 4 to 12 weeks after the implantation of bone cements, the bone volume fraction (BV/TV) of the PSMBBC group increased from 28.27 ± 1.69% to 38.43 ± 1.34%. However, the BV/TV of the PMMA group showed no significant difference after the implantation. At 4 weeks, direct contact between the bone and the bone cement was observed in the PSMBBC group. At 12 weeks, it was discovered that new intact bone trabecular was formed in PSMBBC group. Furthermore, the maximum compressive strength values of the PSMBBC group were significantly higher than those of the control group at each time point after implantation. CONCLUSIONS: In summary, this study was the first investigation to evaluate the potential application of PSMBBC for vertebroplasty. RESULTS demonstrated its beneficial effects on the trabecular ingrowth of new bone and bone mineral density increase. With further validation, PSMBBC can become a valuable biomaterial for aiding osteoporotic vertebrae and usable bone cement applied in vertebroplasty.
Entities:
Keywords:
Osteoporosis; bioglass; bone cement; vertebroplasty
Authors: S Castañeda; R Largo; E Calvo; F Rodríguez-Salvanés; M E Marcos; M Díaz-Curiel; G Herrero-Beaumont Journal: Skeletal Radiol Date: 2005-10-25 Impact factor: 2.199