Wenru Tang1, Yang Yang, Bin Wang, Chunjie Xiao. 1. Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center of Yunnan University, Kunming, Yunnan, PR, China.
Abstract
BACKGROUND: Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure. We investigated the association between this polymorphism and essential hypertension (EH) in Hani (n=305 individuals) and Yi (n=233 individuals) minorities of China. METHODS: eNOS genotyping with polymerase chain reaction-restriction fragment length polymorphism was performed in 267 normotensive (NT) subjects and 271 EH subjects. RESULTS: The frequencies of eNOS G894T genotypes in NT controls and EH cohort in Hani population were GG: 0.714 vs. 0.581; GT+TT: 0.286 vs. 0.419, respectively. The frequencies of eNOS G894T genotypes in NT controls and EH cohort in Yi population were GG: 0.552 vs. 0.717; GT+TT: 0.448 vs. 0.283, respectively. There was a significant difference in G894T genotype distribution between NTs and hypertensives in both Hani and Yi populations (p<0.05). CONCLUSIONS: The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.
BACKGROUND:Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure. We investigated the association between this polymorphism and essential hypertension (EH) in Hani (n=305 individuals) and Yi (n=233 individuals) minorities of China. METHODS:eNOS genotyping with polymerase chain reaction-restriction fragment length polymorphism was performed in 267 normotensive (NT) subjects and 271 EH subjects. RESULTS: The frequencies of eNOSG894T genotypes in NT controls and EH cohort in Hani population were GG: 0.714 vs. 0.581; GT+TT: 0.286 vs. 0.419, respectively. The frequencies of eNOSG894T genotypes in NT controls and EH cohort in Yi population were GG: 0.552 vs. 0.717; GT+TT: 0.448 vs. 0.283, respectively. There was a significant difference in G894T genotype distribution between NTs and hypertensives in both Hani and Yi populations (p<0.05). CONCLUSIONS: The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.
Authors: Brehima Diakite; Khalil Hamzi; Ilham Slassi; Mohammed El Yahyaoui; Moulay M F El Alaoui; Rachida Habbal; Nadifi Sellama Journal: Meta Gene Date: 2014-05-07
Authors: Roberta Fernanda da Silva; Átila Alexandre Trapé; Thaís Amanda Reia; Riccardo Lacchini; Gustavo Henrique Oliveira-Paula; Lucas Cezar Pinheiro; José Eduardo Tanus-Santos; André Mourão Jacomini; Carlos Roberto Bueno Júnior; Anderson Saranz Zago Journal: PLoS One Date: 2018-10-18 Impact factor: 3.240