PURPOSE OF REVIEW: Ocular surface disorder underlies a diverse group of prevalent diseases in the United States, caused by biological aging, autoimmune conditions, trauma, or iatrogenic factors. Left untreated, these conditions can progress to vision loss or destruction of the globe itself. This review discusses the most recent and relevant clinical and experimental advances in the treatment options for ocular surface disorders. RECENT FINDINGS: Current literature suggests that recent progress in tissue bioengineering, and molecular and cellular biology research presents many potential interventional therapies for ocular surface diseases. Depending on the pathogenesis of each condition, treatment options include bioengineered amniotic membrane graft, limbal stem cell transplantation, conjunctival and extraocular tissue transplantation, multiagent immunosuppressant therapy, and bioartificial devices such as lacrimal gland microdevices and keratoprostheses, or tissue adhesives. SUMMARY: Much progress has been made in the fields of microbiology, stem-cell research, tissue engineering, and bioartificial devices for the treatment of the heterogeneous group of ocular surface disorders. Intensive efforts are underway to ensure the adaptation and accessibility of these therapeutic options to the general population.
PURPOSE OF REVIEW: Ocular surface disorder underlies a diverse group of prevalent diseases in the United States, caused by biological aging, autoimmune conditions, trauma, or iatrogenic factors. Left untreated, these conditions can progress to vision loss or destruction of the globe itself. This review discusses the most recent and relevant clinical and experimental advances in the treatment options for ocular surface disorders. RECENT FINDINGS: Current literature suggests that recent progress in tissue bioengineering, and molecular and cellular biology research presents many potential interventional therapies for ocular surface diseases. Depending on the pathogenesis of each condition, treatment options include bioengineered amniotic membrane graft, limbal stem cell transplantation, conjunctival and extraocular tissue transplantation, multiagent immunosuppressant therapy, and bioartificial devices such as lacrimal gland microdevices and keratoprostheses, or tissue adhesives. SUMMARY: Much progress has been made in the fields of microbiology, stem-cell research, tissue engineering, and bioartificial devices for the treatment of the heterogeneous group of ocular surface disorders. Intensive efforts are underway to ensure the adaptation and accessibility of these therapeutic options to the general population.
Authors: Pho Nguyen; David Huang; Yan Li; Srinivas R Sadda; Sylvia Ramos; Rajeev R Pappuru; Samuel C Yiu Journal: Cornea Date: 2012-06 Impact factor: 2.651
Authors: Kai B Kang; Brian D Lawrence; X Raymond Gao; Yuncin Luo; Qiang Zhou; Aihong Liu; Victor H Guaiquil; Mark I Rosenblatt Journal: Invest Ophthalmol Vis Sci Date: 2017-12-01 Impact factor: 4.799
Authors: Waleed Abdel-Naby; Brigette Cole; Aihong Liu; Jingbo Liu; Pengxia Wan; Victor H Guaiquil; Ryan Schreiner; David Infanger; Brian D Lawrence; Mark I Rosenblatt Journal: Invest Ophthalmol Vis Sci Date: 2017-03-01 Impact factor: 4.799
Authors: Pius Agbenorku; Joseph Akpaloo; Facharzt Chirurgie; Ken Aboah; Ellen Klutsey; Paa Ekow Hoyte-Williams; Boutros Farhat; Edmund Turkson; Joseph Yorke; Facharzt Chirurgie; Richard Ametih; Romeo Hussey Journal: Plast Reconstr Surg Glob Open Date: 2015-10-23