Literature DB >> 18161915

Genetic and epigenetic changes associated with cholangiocarcinoma: from DNA methylation to microRNAs.

Monique Stutes1, Steven Tran, Sharon DeMorrow.   

Abstract

Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations (by microRNA expression) and epigenetic changes (hypermethylation of specific gene promoters) that are thought to contribute to the carcinogenic process in cholangiocarcinoma.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18161915      PMCID： PMC4611284          DOI： 10.3748/wjg.v13.i48.6465

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  48 in total

1.  High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma.

Authors:  Markus Metzler; Monika Wilda; Kerstin Busch; Susanne Viehmann; Arndt Borkhardt
Journal:  Genes Chromosomes Cancer       Date:  2004-02       Impact factor: 5.006

Review 2.  Gene silencing by methyl-CpG-binding proteins.

Authors:  X Nan; S Cross; A Bird
Journal:  Novartis Found Symp       Date:  1998

Review 3.  A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes.

Authors:  O A Kent; J T Mendell
Journal:  Oncogene       Date:  2006-10-09       Impact factor: 9.867

4.  Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States.

Authors:  Luciana McLean; Tushar Patel
Journal:  Liver Int       Date:  2006-11       Impact factor: 5.828

5.  Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

Authors:  George Adrian Calin; Cinzia Sevignani; Calin Dan Dumitru; Terry Hyslop; Evan Noch; Sai Yendamuri; Masayoshi Shimizu; Sashi Rattan; Florencia Bullrich; Massimo Negrini; Carlo M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-18       Impact factor: 11.205

6.  Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling.

Authors:  Daniel R Scoles; Vu D Nguyen; Yun Qin; Chun-Xiao Sun; Helen Morrison; David H Gutmann; Stefan-M Pulst
Journal:  Hum Mol Genet       Date:  2002-12-01       Impact factor: 6.150

Review 7.  Molecular control of the cell cycle in cancer: biological and clinical aspects.

Authors:  Michael Boe Møller
Journal:  Dan Med Bull       Date:  2003-05

8.  Relationship between interleukin-6 and proliferation and differentiation in cholangiocarcinoma.

Authors:  H Sugawara; M Yasoshima; K Katayanagi; N Kono; Y Watanabe; K Harada; Y Nakanuma
Journal:  Histopathology       Date:  1998-08       Impact factor: 5.087

9.  Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma.

Authors:  Andrea Tannapfel; Florian Sommerer; Markus Benicke; Lars Weinans; Alexander Katalinic; Felix Geissler; Dirk Uhlmann; Johann Hauss; Christian Wittekind
Journal:  J Pathol       Date:  2002-08       Impact factor: 7.996

Review 10.  Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer.

Authors:  Adam R Karpf
Journal:  Curr Opin Mol Ther       Date:  2007-06
View more
  12 in total

Review 1.  MicroRNAs in biliary diseases.

Authors:  Patricia Munoz-Garrido; Maite García-Fernández de Barrena; Elizabeth Hijona; Miguel Carracedo; José J G Marín; Luis Bujanda; Jesús M Banales
Journal:  World J Gastroenterol       Date:  2012-11-21       Impact factor: 5.742

Review 2.  Recent advances in the regulation of cholangiocarcinoma growth.

Authors:  Heather Francis; Gianfranco Alpini; Sharon DeMorrow
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-04-29       Impact factor: 4.052

Review 3.  Genetic profiling of intrahepatic cholangiocarcinoma.

Authors:  Jesper B Andersen; Snorri S Thorgeirsson
Journal:  Curr Opin Gastroenterol       Date:  2012-05       Impact factor: 3.287

4.  Molecular mechanisms of cholangiocarcinoma.

Authors:  Giammarco Fava
Journal:  World J Gastrointest Pathophysiol       Date:  2010-04-15

5.  Aberrant DNA methylation profile in cholangiocarcinoma.

Authors:  Li Huang; Gabriel Frampton; Li-Jian Liang; Sharon Demorrow
Journal:  World J Gastrointest Pathophysiol       Date:  2010-06-15

6.  Mutual regulation between microRNA-373 and methyl-CpG-binding domain protein 2 in hilar cholangiocarcinoma.

Authors:  Yong-Jun Chen; Jian Luo; Guang-Yao Yang; Kang Yang; Song-Qi Wen; Sheng-Quan Zou
Journal:  World J Gastroenterol       Date:  2012-08-07       Impact factor: 5.742

Review 7.  Emerging insights into the role of microRNAs in the pathogenesis of cholangiocarcinoma.

Authors:  Hiroaki Haga; Irene Yan; Kenji Takahashi; Joseph Wood; Tushar Patel
Journal:  Gene Expr       Date:  2014

8.  A six-microRNA set as prognostic indicators for bile duct cancer.

Authors:  Ming Wang; Tian-Fu Wen; Lin-Hai He; Chuan Li; Wen-Jiang Zhu; Narasimha Murthy Trishul
Journal:  Int J Clin Exp Med       Date:  2015-10-15

9.  Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth.

Authors:  Gianfranco Alpini; Pietro Invernizzi; Eugenio Gaudio; Julie Venter; Shelley Kopriva; Francesca Bernuzzi; Paolo Onori; Antonio Franchitto; Monique Coufal; Gabriel Frampton; Domenico Alvaro; Sum P Lee; Marco Marzioni; Antonio Benedetti; Sharon DeMorrow
Journal:  Cancer Res       Date:  2008-11-15       Impact factor: 12.701

10.  ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth.

Authors:  Steffen Kiehl; Stefanie C Herkt; Antje M Richter; Liesa Fuhrmann; Nefertiti El-Nikhely; Werner Seeger; Rajkumar Savai; Reinhard H Dammann
Journal:  Sci Rep       Date:  2014-11-04       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.