Literature DB >> 18160525

Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.

Cristina Rueda1, Soledad Fenoy, Fernando Simón, Carmen Del Aguila.   

Abstract

The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18160525      PMCID： PMC2258538          DOI： 10.1128/AAC.01019-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Pathogenesis of Cryptosporidium parvum infection.

Authors:  F Laurent; D McCole; L Eckmann; M F Kagnoff
Journal:  Microbes Infect       Date:  1999-02       Impact factor: 2.700

Review 2.  Cryptosporidium and cryptosporidiosis.

Authors:  R C A Thompson; M E Olson; G Zhu; S Enomoto; Mitchell S Abrahamsen; N S Hijjawi
Journal:  Adv Parasitol       Date:  2005       Impact factor: 3.870

3.  Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells.

Authors:  Amna Hashim; Grace Mulcahy; Billy Bourke; Marguerite Clyne
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

4.  In vitro and in vivo analysis of the thyroid disrupting activities of phenolic and phenol compounds in Xenopus laevis.

Authors:  Yumiko Kudo; Kiyoshi Yamauchi
Journal:  Toxicol Sci       Date:  2004-12-08       Impact factor: 4.849

5.  Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells.

Authors:  X M Chen; N F LaRusso
Journal:  Gastroenterology       Date:  2000-02       Impact factor: 22.682

6.  Ultrastructure, immunofluorescence, western blot, and PCR analysis of eight isolates of Encephalitozoon (Septata) intestinalis established in culture from sputum and urine samples and duodenal aspirates of five patients with AIDS.

Authors:  G P Croppo; G P Croppo; H Moura; A J Da Silva; G J Leitch; D M Moss; S Wallace; S B Slemenda; N J Pieniazek; G S Visvesvara
Journal:  J Clin Microbiol       Date:  1998-05       Impact factor: 5.948

7.  Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor.

Authors:  Iñaki F Trocóniz; Ilonka Zsolt; María J Garrido; Marta Valle; Rosa M Antonijoan; Manel J Barbanoj
Journal:  Pharm Res       Date:  2006-06-21       Impact factor: 4.200

8.  Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models.

Authors:  C M Theodos; J K Griffiths; J D'Onfro; A Fairfield; S Tzipori
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

9.  High-performance liquid chromatography analysis of Bobel-24 in biological samples for pharmacokinetic, metabolic and tissue distribution studies.

Authors:  L García-Capdevila; C López-Calull; S Pompermayer; C Arroyo; A M Molins-Pujol; J Bonal
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1998-04-24

10.  Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.

Authors:  J R Mead; X You; J E Pharr; Y Belenkaya; M J Arrowood; M T Fallon; R F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191
View more
  3 in total

1.  Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.

Authors:  Suresh Kumar Gorla; Nina N McNair; Guangyi Yang; Song Gao; Ming Hu; Venkatakrishna R Jala; Bodduluri Haribabu; Boris Striepen; Gregory D Cuny; Jan R Mead; Lizbeth Hedstrom
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191

2.  Kinetic properties and small-molecule inhibition of human myosin-6.

Authors:  Sarah M Heissler; Jayashankar Selvadurai; Lisa M Bond; Roman Fedorov; John Kendrick-Jones; Folma Buss; Dietmar J Manstein
Journal:  FEBS Lett       Date:  2012-07-31       Impact factor: 4.124

3.  Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs.

Authors:  José Antonio Castro-Hermida; Ignacio García-Presedo; Marta González-Warleta; Mercedes Mezo; Soledad Fenoy; Cristina Rueda; Carmen del Aguila
Journal:  Vet Parasitol       Date:  2008-05-22       Impact factor: 2.738
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.