| Literature DB >> 18160033 |
Abstract
Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.Entities:
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Year: 2007 PMID： 18160033 DOI： 10.1016/j.cell.2007.12.007
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582