Literature DB >> 18160031

RNA polymerase I: a multifunctional molecular machine.

Jeremy R Haag1, Craig S Pikaard.   

Abstract

In this issue, Kuhn et al. (2007) report the complete structure of the 14-subunit yeast RNA polymerase (Pol) I enzyme at 12 A resolution using cryo-electron microscopy (cryo-EM). Their study reveals that three subunits of Pol I perform functions in transcription elongation that are outsourced to the transcription factors TFIIF and TFIIS in the analogous Pol II transcription system.

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Year:  2007        PMID: 18160031     DOI: 10.1016/j.cell.2007.12.005

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  11 in total

1.  CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis.

Authors:  Baoyan Bai; Henna M Moore; Marikki Laiho
Journal:  Nucleus       Date:  2013-06-12       Impact factor: 4.197

2.  A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

Authors:  Karita Peltonen; Laureen Colis; Hester Liu; Rishi Trivedi; Michael S Moubarek; Henna M Moore; Baoyan Bai; Michelle A Rudek; Charles J Bieberich; Marikki Laiho
Journal:  Cancer Cell       Date:  2014-01-13       Impact factor: 31.743

Review 3.  Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.

Authors:  Sarah J Goodfellow; Joost C B M Zomerdijk
Journal:  Subcell Biochem       Date:  2013

4.  Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.

Authors:  Jin-Yih Low; Paul Sirajuddin; Michael Moubarek; Shreya Agarwal; Apurv Rege; Gunes Guner; Hester Liu; Zhiming Yang; Angelo M De Marzo; Charles Bieberich; Marikki Laiho
Journal:  Prostate       Date:  2019-09-16       Impact factor: 4.104

5.  Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.

Authors:  Laureen Colis; Glen Ernst; Sara Sanders; Hester Liu; Paul Sirajuddin; Karita Peltonen; Michael DePasquale; James C Barrow; Marikki Laiho
Journal:  J Med Chem       Date:  2014-05-30       Impact factor: 7.446

6.  DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response.

Authors:  Laureen Colis; Karita Peltonen; Paul Sirajuddin; Hester Liu; Sara Sanders; Glen Ernst; James C Barrow; Marikki Laiho
Journal:  Oncotarget       Date:  2014-06-30

7.  RNAP II produces capped 18S and 25S ribosomal RNAs resistant to 5'-monophosphate dependent processive 5' to 3' exonuclease in polymerase switched Saccharomyces cerevisiae.

Authors:  Miguel A Rocha; Bhavani S Gowda; Jacob Fleischmann
Journal:  BMC Mol Cell Biol       Date:  2022-04-10

8.  Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs.

Authors:  Baoyan Bai; Hester Liu; Marikki Laiho
Journal:  FEBS Open Bio       Date:  2014-05-02       Impact factor: 2.693

9.  Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.

Authors:  Ting Wei; Saman M Najmi; Hester Liu; Karita Peltonen; Alena Kucerova; David A Schneider; Marikki Laiho
Journal:  Cell Rep       Date:  2018-04-10       Impact factor: 9.423

10.  Exonuclease resistant 18S and 25S ribosomal RNA components in yeast are possibly newly transcribed by RNA polymerase II.

Authors:  Jacob Fleischmann; Miguel A Rocha; Peter V Hauser; Bhavani S Gowda; Mary Grace D Pilapil
Journal:  BMC Mol Cell Biol       Date:  2020-08-01
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