| Literature DB >> 18157154 |
Rotem Sorek1, Victor Kunin, Philip Hugenholtz.
Abstract
Arrays of clustered, regularly interspaced short palindromic repeats (CRISPRs) are widespread in the genomes of many bacteria and almost all archaea. These arrays are composed of direct repeats that are separated by similarly sized non-repetitive spacers. CRISPR arrays, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism. This Progress discusses the structure and function of this newly recognized antiviral mechanism.Mesh:
Substances:
Year: 2008 PMID: 18157154 DOI: 10.1038/nrmicro1793
Source DB: PubMed Journal: Nat Rev Microbiol ISSN: 1740-1526 Impact factor: 60.633