OBJECTIVE: In response to a recent ecologic study of UV exposure and endometrial cancer incidence, we present the epidemiologic evidence on the relation between intake of vitamin D and its metabolically related nutrient, calcium, and the occurrence of endometrial cancer. METHODS: We conducted a systematic literature review and meta-analysis of vitamin D and calcium in relation to endometrial cancer, including peer-reviewed manuscripts published up to May 2007. Random and fixed effects summary estimates were computed. RESULTS: Pooled analyses of the three case-control studies of dietary vitamin D and endometrial cancer uncovered heterogeneous results that were not significant in random or fixed effects analyses. Cut-points for the highest vitamin D intakes ranged from >244 to >476 IU/day. Qualitatively similar findings were observed for dietary calcium. Only two studies provided estimates for calcium supplements (random effects OR=0.62, 95% CI 0.39-0.99; fixed effects OR=0.62, 95% CI 0.42-0.93, for top vs. bottom category, p for heterogeneity=0.25). CONCLUSIONS: The limited epidemiological evidence suggests no relation between endometrial cancer in the ranges of dietary vitamin D examined, and suggests a possible inverse association for calcium from supplements. Prospective studies, ideally including plasma 25(OH) D to estimate vitamin D input from diet and sun exposure, are needed to further explore these hypotheses.
OBJECTIVE: In response to a recent ecologic study of UV exposure and endometrial cancer incidence, we present the epidemiologic evidence on the relation between intake of vitamin D and its metabolically related nutrient, calcium, and the occurrence of endometrial cancer. METHODS: We conducted a systematic literature review and meta-analysis of vitamin D and calcium in relation to endometrial cancer, including peer-reviewed manuscripts published up to May 2007. Random and fixed effects summary estimates were computed. RESULTS: Pooled analyses of the three case-control studies of dietary vitamin D and endometrial cancer uncovered heterogeneous results that were not significant in random or fixed effects analyses. Cut-points for the highest vitamin D intakes ranged from >244 to >476 IU/day. Qualitatively similar findings were observed for dietary calcium. Only two studies provided estimates for calcium supplements (random effects OR=0.62, 95% CI 0.39-0.99; fixed effects OR=0.62, 95% CI 0.42-0.93, for top vs. bottom category, p for heterogeneity=0.25). CONCLUSIONS: The limited epidemiological evidence suggests no relation between endometrial cancer in the ranges of dietary vitamin D examined, and suggests a possible inverse association for calcium from supplements. Prospective studies, ideally including plasma 25(OH) D to estimate vitamin D input from diet and sun exposure, are needed to further explore these hypotheses.
Authors: E Salazar-Martinez; E Lazcano-Ponce; L M Sanchez-Zamorano; G Gonzalez-Lira; P Escudero-DE Los Rios; M Hernandez-Avila Journal: Int J Gynecol Cancer Date: 2005 Sep-Oct Impact factor: 3.437
Authors: Marjorie L McCullough; Carmen Rodriguez; W Ryan Diver; Heather Spencer Feigelson; Victoria L Stevens; Michael J Thun; Eugenia E Calle Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-12 Impact factor: 4.254
Authors: Edward Giovannucci; Yan Liu; Eric B Rimm; Bruce W Hollis; Charles S Fuchs; Meir J Stampfer; Walter C Willett Journal: J Natl Cancer Inst Date: 2006-04-05 Impact factor: 13.506
Authors: Elizabeth R Bertone-Johnson; Wendy Y Chen; Michael F Holick; Bruce W Hollis; Graham A Colditz; Walter C Willett; Susan E Hankinson Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-08 Impact factor: 4.254
Authors: Wei Yu; Mark Cline; Larry G Maxwell; David Berrigan; Gustavo Rodriguez; Anni Warri; Leena Hilakivi-Clarke Journal: Cancer Prev Res (Phila) Date: 2010-09-21
Authors: Qian Li; Shu-Chun Chuang; Jose Eluf-Neto; Ana Menezes; Elena Matos; Sergio Koifman; Victor Wünsch-Filho; Leticia Fernandez; Alexander W Daudt; Maria Paula Curado; Deborah M Winn; Silvia Franceschi; Rolando Herrero; Xavier Castellsague; Hal Morgenstern; Zuo-Feng Zhang; Philip Lazarus; Joshua Muscat; Michael McClean; Karl T Kelsey; Richard B Hayes; Mark P Purdue; Stephen M Schwartz; Chu Chen; Simone Benhamou; Andrew F Olshan; Guopei Yu; Stimson Schantz; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Int J Cancer Date: 2012-01-27 Impact factor: 7.396
Authors: Anne Zeleniuch-Jacquotte; Lisa Gallicchio; Virginia Hartmuller; Kathy J Helzlsouer; Marjorie L McCullough; V Wendy Setiawan; Xiao-Ou Shu; Stephanie J Weinstein; Jocelyn M Weiss; Alan A Arslan; Immaculata De Vivo; Yu-Tang Gao; Richard B Hayes; Brian E Henderson; Ronald L Horst; Karen L Koenig; Alpa V Patel; Mark P Purdue; Kirk Snyder; Emily Steplowski; Kai Yu; Wei Zheng; Susan E Hankinson Journal: Am J Epidemiol Date: 2010-06-18 Impact factor: 4.897
Authors: J J Liu; K A Bertrand; S Karageorgi; E Giovannucci; S E Hankinson; B Rosner; L Maxwell; G Rodriguez; I De Vivo Journal: Ann Oncol Date: 2012-11-07 Impact factor: 51.769