Literature DB >> 18137299

Nephrotoxic nephritis in rats; evidence for the glomerular origin of the kidney antigen.

D H SOLOMON, J W GARDELLA.   

Abstract

Nephrotoxic anti-rat kidney sera were produced in rabbits by intraperitoneal injection of suspensions of blood-free rat kidney. The nephrotoxin of these sera could be removed by adsorption with saline suspensions of finely ground rat glomeruli, but not by adsorption with other portions of rat kidney or by adsorption with several other rat tissues. It was concluded that nephrotoxic sera of this type react primarily with glomerular tissue and, by inference, that the antigen essential for the production of these anti-kidney sera was of glomerular origin. The observations are consistent with Pressman's (15, 16) demonstration that anti-mouse kidney sera labeled with radioiodine localize primarily in glomeruli.

Entities:  

Keywords:  NEPHRITIS/experimental

Mesh：

Substances：

Year:  1949        PMID： 18137299      PMCID： PMC2135908          DOI： 10.1084/jem.90.3.267

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  6 in total

1.  CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. I. THE CHARACTERIZATION OF THE PROTEIN FRACTIONS OF HUMAN PLASMA.

Authors:  E J Cohn; J L Oncley; L E Strong; W L Hughes; S H Armstrong
Journal:  J Clin Invest       Date:  1944-07       Impact factor: 14.808

2.  The Zone of Localization of Anti-Mouse-Kidney Serum as Determined by Radioautographs.

Authors:  D Pressman; R F Hill; F W Foote
Journal:  Science       Date:  1949-01-21       Impact factor: 47.728

3.  EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : III. PATHOLOGICAL STUDIES OF THE ACUTE AND CHRONIC DISEASE.

Authors:  J E Smadel
Journal:  J Exp Med       Date:  1937-03-31       Impact factor: 14.307

4.  EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : I. PREPARATION AND IMMUNOLOGICAL STUDIES OF NEPHROTOXIN.

Authors:  J E Smadel
Journal:  J Exp Med       Date:  1936-11-30       Impact factor: 14.307

5.  EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : IV. PREVENTION OF THE INJURIOUS EFFECTS OF NEPHROTOXIN IN VIVO BY KIDNEY EXTRACT.

Authors:  H F Swift; J E Smadel
Journal:  J Exp Med       Date:  1937-03-31       Impact factor: 14.307

6.  EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : II. CLINICAL AND FUNCTIONAL STUDIES.

Authors:  J E Smadel; L E Farr
Journal:  J Exp Med       Date:  1937-03-31       Impact factor: 14.307
  6 in total
  8 in total

1.  [The problem of auto-antibodies].

Authors:  H HARDERS
Journal:  Klin Wochenschr       Date:  1954-09-01

2.  [Experimental nephritis in animals with special reference to the so-called Calvelti's nephritis].

Authors:  A BOHLE; H J KRECKE; H KLEINMAIER; K GOERGEN
Journal:  Arch Kreislaufforsch       Date:  1954-12

3.  [Humoral factors in the pathogenesis of the human hypertension].

Authors:  J MOELLER
Journal:  Arch Kreislaufforsch       Date:  1952-09

4.  Analytical pathology. IV. The role of localized antibodies in the pathogenesis of nephrotoxic nephritis in the rat.

Authors:  L G ORTEGA; R C MELLORS
Journal:  J Exp Med       Date:  1956-07-01       Impact factor: 14.307

5.  Nephrotoxic serum nephritis in rats. I. Distribution and specificity of the antigen responsible for the production of nephrotoxic antibodies.

Authors:  J H BAXTER; H C GOODMAN
Journal:  J Exp Med       Date:  1956-10-01       Impact factor: 14.307

6.  A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS.

Authors:  C G COCHRANE; E R UNANUE; F J DIXON
Journal:  J Exp Med       Date:  1965-07-01       Impact factor: 14.307

7.  Studies on acute disseminated encephalomyelitis produced experimentally in Rhesus monkeys; complement-fixing antibodies.

Authors:  C E LUMSDEN; E A KABAT; A WOLF; A E BEZER
Journal:  J Exp Med       Date:  1950-09       Impact factor: 14.307

8.  Experimental glomerulonephritis. II. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat.

Authors:  D K HAMMER; F J DIXON
Journal:  J Exp Med       Date:  1963-06-01       Impact factor: 14.307
  8 in total

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