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Literature DB >> 13952379

Experimental glomerulonephritis. II. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat.

Abstract

The primary phase of nephrotoxic serum nephritis produced by rabbit nephrotoxic serum appears to be dependent to a great extent, but not completely, upon the participation of serum complement. On the other hand, duck nephrotoxic serum produces its primary renal injury without detectable utilization of or dependence upon serum complement. The secondary phase of nephrotoxic serum nephritis appears to be largely or entirely dependent upon the host's antibody response to the heterologous gamma globulin fixed in the glomeruli. No evidence could be obtained for the existence of an autoimmune antikidney response by the host in this experimental model.

Entities: Disease Species

Keywords: GLOMERULONEPHRITIS

Mesh：

Substances：

Year: 1963 PMID： 13952379 PMCID： PMC2137595 DOI： 10.1084/jem.117.6.1019

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

26 in total

1. [Studies on transmission of Masugi's nephritis in rat; transmission of by parabiosis of short duration].

Authors: E F PFEIFFER; K SCHOFFLING; W SANDRITTER; J SCHRODER; H STEIGERWALD; L WOLF
Journal: Z Gesamte Exp Med Date: 1954

2. Immunologic mechanism of transmission of experimental glomerulonephritis in parabiotic rats.

Authors: K LANGE; M WACHSTEIN; S E MCPHERSON
Journal: Proc Soc Exp Biol Med Date: 1961-01

3. Immune reactions in human glomerulonephritis.

Authors: E E FISCHEL
Journal: J Chronic Dis Date: 1957-01

4. Reduction of serum complement following in vivo tissue antigen-antibody reactions.

Authors: A B STAVITSKY; D B HACKEL; W HEYMANN
Journal: Proc Soc Exp Biol Med Date: 1954-04

5. Diagnostic complement fixation. I. A method.

Authors: A G OSLER; J H STRAUSS; M M MAYER
Journal: Am J Syph Gonorrhea Vener Dis Date: 1952-03

6. Nephrotic syndrome in rats.

Authors: W HEYMANN; H Z LUND
Journal: Pediatrics Date: 1951-05 Impact factor: 7.124

7. Immediate or delayed nephritis in rats produced by duck anti-rat-kidney sera.

Authors: M W HASSON; M BEVANS; B C SEEGAL
Journal: AMA Arch Pathol Date: 1957-08

8. Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.

Authors: W HEYMANN; D B HACKEL; S HARWOOD; S G WILSON; J L HUNTER
Journal: Proc Soc Exp Biol Med Date: 1959-04

9. Characterization of the reactant (gamma globulin factor) in the F II precipitin reaction and the F II tanned sheep cell agglutination test.

Authors: C L CHRISTIAN
Journal: J Exp Med Date: 1958-07-01 Impact factor: 14.307

10. Nephrotoxic nephritis in rats; evidence for the glomerular origin of the kidney antigen.

Authors: D H SOLOMON; J W GARDELLA
Journal: J Exp Med Date: 1949-09 Impact factor: 14.307

55 in total

1. The role of C3 in the autologous phase of nephrotoxic nephritis.

Authors: N M Thomson; P F Naish; I J Simpson; D K Peters
Journal: Clin Exp Immunol Date: 1976-06 Impact factor: 4.330

2. Reactive oxygen products in heterologous anti-glomerular basement membrane nephritis in rats.

Authors: R J Birtwistle; J Michael; A J Howie; D Adu
Journal: Br J Exp Pathol Date: 1989-04

3. Antibody-induced glomerular injury.

Authors: H G Rennke
Journal: Klin Wochenschr Date: 1985-09-16

4. [Immunohistological observations in minimal changes-, and focal sclerosing glomerulopathy with nephrotic syndrome (author's transl)].

Authors: G H Thoenes
Journal: Klin Wochenschr Date: 1974-04-15

5. Nephritogenic glycoprotein. IV. Induction of proliferative glomerulonephritis with immunofluorescent "mesangial pattern" in rats by a single injection of heterologous renal glycoprotein.

Authors: S Shibata; T Nagasawa
Journal: Immunology Date: 1974-04 Impact factor: 7.397