Literature DB >> 1812893

Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement.

S Kleinau1, H Erlandsson, R Holmdahl, L Klareskog.   

Abstract

An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel A, as well as Pristane oil were arthritogenic, whereas vegetable oil were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.

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Year:  1991        PMID： 1812893      PMCID： PMC7126449          DOI： 10.1016/0896-8411(91)90050-m

Source DB:  PubMed          Journal:  J Autoimmun        ISSN： 0896-8411            Impact factor:   7.094


  12 in total

1.  Studies on adjuvant-induced polyarthritis in rats. I. Adjuvant composition, route of injection, and removal of depot site.

Authors:  J R WARD; R S JONES
Journal:  Arthritis Rheum       Date:  1962-12

2.  Development of arthritis, periarthritis and periostitis in rats given adjuvants.

Authors:  C M PEARSON
Journal:  Proc Soc Exp Biol Med       Date:  1956-01

3.  Homologous type II collagen-induced arthritis in rats. Characterization of the disease and demonstration of clinically distinct forms of arthritis in two strains of rats after immunization with the same collagen preparation.

Authors:  P Larsson; S Kleinau; R Holmdahl; L Klareskog
Journal:  Arthritis Rheum       Date:  1990-05

4.  Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis.

Authors:  O Lider; T Reshef; E Beraud; A Ben-Nun; I R Cohen
Journal:  Science       Date:  1988-01-08       Impact factor: 47.728

5.  Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

Authors:  M W Whitehouse; K J Orr; F W Beck; C M Pearson
Journal:  Immunology       Date:  1974-08       Impact factor: 7.397

6.  Linomide, a new immunomodulatory drug, shows different effects on homologous versus heterologous collagen-induced arthritis in rats.

Authors:  S Kleinau; P Larsson; J Björk; R Holmdahl; L Klareskog
Journal:  Clin Exp Immunol       Date:  1989-10       Impact factor: 4.330

7.  Autoimmune murine thyroiditis relation to histocompatibility (H-2) type.

Authors:  A O Vladutiu; N R Rose
Journal:  Science       Date:  1971-12-10       Impact factor: 47.728

8.  Immunological involvement in the pathogenesis of pristane-induced arthritis.

Authors:  A E Bedwell; C J Elson; C E Hinton
Journal:  Scand J Immunol       Date:  1987-04       Impact factor: 3.487

9.  Genetics of susceptibility to pristane-induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis.

Authors:  M Potter; J S Wax
Journal:  J Immunol       Date:  1981-10       Impact factor: 5.422

10.  Pristane-induced arthritis. The immunologic and genetic features of an experimental murine model of autoimmune disease.

Authors:  P H Wooley; J R Seibold; J D Whalen; J M Chapdelaine
Journal:  Arthritis Rheum       Date:  1989-08
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  37 in total

1.  The arthritogenic adjuvant squalene does not accumulate in joints, but gives rise to pathogenic cells in both draining and non-draining lymph nodes.

Authors:  B C Holm; L Svelander; A Bucht; J C Lorentzen
Journal:  Clin Exp Immunol       Date:  2002-03       Impact factor: 4.330

2.  Polyclonal Th1 cells transfer oil-induced arthritis.

Authors:  L Svelander; A Müssener; H Erlandsson-Harris; S Kleinau
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

3.  Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1β, and joint damage in pristane- and collagen-induced arthritis.

Authors:  Max Brenner; Teresina Laragione; Anish Shah; Adriana Mello; Elaine F Remmers; Ronald L Wilder; Pércio S Gulko
Journal:  Arthritis Rheum       Date:  2012-05

Review 4.  The development and use of vaccine adjuvants.

Authors:  Robert Edelman
Journal:  Mol Biotechnol       Date:  2002-06       Impact factor: 2.695

5.  Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease.

Authors:  R Holmdahl; T J Goldschmidt; S Kleinau; C Kvick; R Jonsson
Journal:  Immunology       Date:  1992-06       Impact factor: 7.397

6.  Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination.

Authors:  David A Zaharoff; Connie J Rogers; Kenneth W Hance; Jeffrey Schlom; John W Greiner
Journal:  Vaccine       Date:  2006-12-04       Impact factor: 3.641

7.  Percutaneous exposure of adjuvant oil causes arthritis in DA rats.

Authors:  S Kleinau; H Erlandsson; L Klareskog
Journal:  Clin Exp Immunol       Date:  1994-05       Impact factor: 4.330

8.  A vitamin D analogue (MC 1288) has immunomodulatory properties and suppresses collagen-induced arthritis (CIA) without causing hypercalcaemia.

Authors:  P Larsson; L Mattsson; L Klareskog; C Johnsson
Journal:  Clin Exp Immunol       Date:  1998-11       Impact factor: 4.330

9.  Regulation of resistance against adjuvant arthritis in the Fisher rat.

Authors:  A G van de Langerijt; P L van Lent; A R Hermus; L B van de Putte; W B van den Berg
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

Review 10.  The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.

Authors:  Emma Ahlqvist; Malin Hultqvist; Rikard Holmdahl
Journal:  Arthritis Res Ther       Date:  2009-05-19       Impact factor: 5.156
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