Literature DB >> 18094714

The role of CALM-AF10 gene fusion in acute leukemia.

D Caudell1, P D Aplan.   

Abstract

Chromosomal translocations are important genetic perturbations frequently associated with hematologic malignancies; characterization of these events has been a rich source of insights into the mechanisms that lead to malignant transformation. The t(10;11)(p13;q14-21) results in a recently identified rare but recurring chromosomal translocation seen in patients with ALL as well as AML, and results in the production of a CALM-AF10 fusion gene. Although the details by which the CALM-AF10 fusion protein exerts its leukemogenic effect remain unclear, emerging data suggests that the CALM-AF10 fusion impairs differentiation of hematopoietic cells, at least in part via an upregulation of HOXA cluster genes. This review discusses the normal structure and function of CALM and AF10, describes the spectrum of clinical findings seen in patients with CALM-AF10 fusions, summarizes recently published CALM-AF10 mouse models and highlights the role of HOXA cluster gene activation in CALM-AF10 leukemia.

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Year:  2007        PMID： 18094714      PMCID： PMC2366104          DOI： 10.1038/sj.leu.2405074

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  71 in total

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Journal:  Nat Rev Cancer       Date:  2001-12       Impact factor: 60.716

2.  The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex.

Authors:  Silvana Debernardi; Alessandra Bassini; Louise K Jones; Tracy Chaplin; Britta Linder; Diederik R H de Bruijn; Eckart Meese; Bryan D Young
Journal:  Blood       Date:  2002-01-01       Impact factor: 22.113

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Journal:  Science       Date:  1998-04-17       Impact factor: 47.728

Review 5.  Endocytosis.

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Journal:  Physiol Rev       Date:  1997-07       Impact factor: 37.312

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Journal:  Annu Rev Biochem       Date:  1997       Impact factor: 23.643

Review 7.  NUP98 gene fusions in hematologic malignancies.

Authors:  D H Lam; P D Aplan
Journal:  Leukemia       Date:  2001-11       Impact factor: 11.528

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Authors:  T H Rabbitts
Journal:  Oncogene       Date:  2001-09-10       Impact factor: 9.867

9.  Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes.

Authors:  H Kobayashi; F Hosoda; N Maseki; M Sakurai; S Imashuku; M Ohki; Y Kaneko
Journal:  Genes Chromosomes Cancer       Date:  1997-11       Impact factor: 5.006

10.  Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis.

Authors:  B Wendland; S D Emr
Journal:  J Cell Biol       Date:  1998-04-06       Impact factor: 10.539
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  27 in total

1.  Lymphadenopathy and hepatosplenomegaly in a patient with acute myelogenous leukaemia.

Authors:  Kota Sato; Michihiro Uchiyama
Journal:  BMJ Case Rep       Date:  2011-12-21

2.  Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.

Authors:  Sarah H Beachy; Masahiro Onozawa; Deborah Silverman; Yang Jo Chung; Mariela Martinez Rivera; Peter D Aplan
Journal:  Exp Hematol       Date:  2013-02-19       Impact factor: 3.084

3.  Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.

Authors:  Liat Goldberg; Sheryl M Gough; Fan Lee; Christine Dang; Robert L Walker; Yuelin J Zhu; Sven Bilke; Marbin Pineda; Masahiro Onozawa; Yang Jo Chung; Paul S Meltzer; Peter D Aplan
Journal:  Genes Chromosomes Cancer       Date:  2017-03-31       Impact factor: 5.006

Review 4.  NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.

Authors:  Sheryl M Gough; Christopher I Slape; Peter D Aplan
Journal:  Blood       Date:  2011-09-26       Impact factor: 22.113

5.  A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.

Authors:  Amanda E Conway; Paula B Scotland; Catherine P Lavau; Daniel S Wechsler
Journal:  Blood       Date:  2013-03-13       Impact factor: 22.113

6.  Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.

Authors:  Rachel L Novak; David P Harper; David Caudell; Christopher Slape; Sarah H Beachy; Peter D Aplan
Journal:  Exp Hematol       Date:  2012-08-08       Impact factor: 3.084

7.  The CALM and CALM/AF10 interactor CATS is a marker for proliferation.

Authors:  Leticia Fröhlich Archangelo; Philipp A Greif; Michael Hölzel; Thomas Harasim; Elisabeth Kremmer; Gerhard K H Przemeck; Dirk Eick; Aniruddha Jayant Deshpande; Christian Buske; Martin Hrabé de Angelis; Sara Teresinha Olalla Saad; Stefan K Bohlander
Journal:  Mol Oncol       Date:  2008-09-04       Impact factor: 6.603

8.  Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.

Authors:  Yoshiaki Shinden; Tadahiro Hirashima; Nijiro Nohata; Hiroko Toda; Reona Okada; Shunichi Asai; Takako Tanaka; Yuto Hozaka; Takao Ohtsuka; Yuko Kijima; Naohiko Seki
Journal:  J Hum Genet       Date:  2020-11-12       Impact factor: 3.172

9.  The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.

Authors:  Daphne C Avgousti; Germano Cecere; Alla Grishok
Journal:  Mol Cell Biol       Date:  2012-12-21       Impact factor: 4.272

10.  Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome.

Authors:  Abdul Gafoor Puthiyaveetil; Christopher M Reilly; Timothy S Pardee; David L Caudell
Journal:  Leuk Res       Date:  2012-11-04       Impact factor: 3.156
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