Literature DB >> 18094215

A perspective on the use of concentration-QT modeling in drug development.

Tanya Russell1, Steven P Riley, Jack A Cook, Richard L Lalonde.   

Abstract

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Year:  2008        PMID: 18094215     DOI: 10.1177/0091270007311115

Source DB:  PubMed          Journal:  J Clin Pharmacol        ISSN: 0091-2700            Impact factor:   3.126


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  5 in total

1.  Estimation of QT interval prolongation through model-averaging.

Authors:  Peter L Bonate
Journal:  J Pharmacokinet Pharmacodyn       Date:  2017-04-18       Impact factor: 2.745

2.  Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates.

Authors:  Puneet Gaitonde; Yeamin Huh; Borje Darpo; Georg Ferber; Günter Heimann; James Li; Kaifeng Lu; Bernard Sebastien; Kuenhi Tsai; Steve Riley
Journal:  J Pharmacokinet Pharmacodyn       Date:  2019-10-30       Impact factor: 2.745

3.  Moxifloxacin versus placebo modeling of the QT interval.

Authors:  Philippe Grosjean; Saïk Urien
Journal:  J Pharmacokinet Pharmacodyn       Date:  2012-02-17       Impact factor: 2.745

4.  Losmapimod concentration-QT relationship in healthy volunteers: meta-analysis of data from six clinical trials.

Authors:  Shuying Yang; Misba Beerahee
Journal:  Eur J Clin Pharmacol       Date:  2013-01-17       Impact factor: 2.953

5.  Concentration-QT analysis of the randomized, placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects.

Authors:  Rashmi Mehta; Michelle Green; Bela Patel; Jonathan Wagg
Journal:  J Pharmacokinet Pharmacodyn       Date:  2016-01-06       Impact factor: 2.745

  5 in total

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