Literature DB >> 18093799

Toxicity testing in the 21st century: a vision and a strategy.

Steven Gibb1.   

Abstract

Advances in molecular biology, biotechnology, and other fields are paving the way for major improvements in how scientists evaluate the health risks posed by potentially toxic chemicals found at low levels in the environment. These advances would make toxicity testing quicker, less expensive, and more directly relevant to human exposures. This National Research Council report creates a far-reaching vision for the future of toxicity testing.

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Mesh:

Year:  2007        PMID: 18093799     DOI: 10.1016/j.reprotox.2007.10.013

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN: 0890-6238            Impact factor:   3.143


  38 in total

1.  Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.

Authors:  Stephanie M Martinez; Blair U Bradford; Valerie Y Soldatow; Oksana Kosyk; Amelia Sandot; Rafal Witek; Robert Kaiser; Todd Stewart; Kirsten Amaral; Kimberly Freeman; Chris Black; Edward L LeCluyse; Stephen S Ferguson; Ivan Rusyn
Journal:  Toxicol Appl Pharmacol       Date:  2010-09-24       Impact factor: 4.219

2.  Toxicology. Transforming environmental health protection.

Authors:  Francis S Collins; George M Gray; John R Bucher
Journal:  Science       Date:  2008-02-15       Impact factor: 47.728

Review 3.  DNA microarray-based gene expression profiling of estrogenic chemicals.

Authors:  Ryoiti Kiyama; Yun Zhu
Journal:  Cell Mol Life Sci       Date:  2014-01-08       Impact factor: 9.261

4.  Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS).

Authors:  Rong Xu; Quanqiu Wang
Journal:  J Biomed Inform       Date:  2013-10-28       Impact factor: 6.317

Review 5.  No time to lose--high throughput screening to assess nanomaterial safety.

Authors:  R Damoiseaux; S George; M Li; S Pokhrel; Z Ji; B France; T Xia; E Suarez; R Rallo; L Mädler; Y Cohen; E M V Hoek; A Nel
Journal:  Nanoscale       Date:  2011-02-07       Impact factor: 7.790

6.  Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.

Authors:  O B Usta; W J McCarty; S Bale; M Hegde; R Jindal; A Bhushan; I Golberg; M L Yarmush
Journal:  Technology (Singap World Sci)       Date:  2015-03

Review 7.  Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity.

Authors:  Alison Hege Harrill; Ivan Rusyn
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-11       Impact factor: 4.481

8.  tcTKB: an integrated cardiovascular toxicity knowledge base for targeted cancer drugs.

Authors:  Rong Xu; QuanQiu Wang
Journal:  AMIA Annu Symp Proc       Date:  2015-11-05

9.  Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors.

Authors:  Christophe Morisseau; Oleg Merzlikin; Amy Lin; Guochun He; Wei Feng; Isela Padilla; Michael S Denison; Isaac N Pessah; Bruce D Hammock
Journal:  Environ Health Perspect       Date:  2009-07-31       Impact factor: 9.031

10.  The Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds.

Authors:  Elizabeth Julien; Alan R Boobis; Stephen S Olin
Journal:  Crit Rev Food Sci Nutr       Date:  2009-09       Impact factor: 11.176

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