| Literature DB >> 18093140 |
Lin-Hui Su1, Chishih Chu, Axel Cloeckaert, Cheng-Hsun Chiu.
Abstract
CTX-M- and AmpC-type beta-lactamases comprise the two most rapidly growing populations among the extended-spectrum cephalosporinases. The evolution and dissemination of resistance genes encoding these enzymes occur mostly through the transmission of plasmids. The high prevalence of clinical isolates of Enterobacteriaceae producing the plasmid-mediated extended-spectrum cephalosporinases resembles an epidemic of plasmids, and has generated serious therapeutic problems. This review describes the emergence and worldwide spread of various classes of plasmid-mediated extended-spectrum cephalosporinases in Salmonella and other Enterobacteriaceae, the transfer mechanism of the plasmids, detection methods, and therapeutic choices.Mesh:
Substances:
Year: 2007 PMID: 18093140 DOI: 10.1111/j.1574-695X.2007.00360.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN: 0928-8244