Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Association between SORL1 and Alzheimer's disease in a genome-wide study.

Literature DB >> 18090307

Association between SORL1 and Alzheimer's disease in a genome-wide study.

Yan Meng¹, Joseph H Lee, Rong Cheng, Peter St George-Hyslop, Richard Mayeux, Lindsay A Farrer.

Abstract

Several studies have reported an association of Alzheimer's disease (AD) with polymorphic markers in SORL1. Data from a recently published genome-wide association study in AD have been made publicly available. We tested the association of AD with SORL1 in this dataset (Translational Genomics Research Institute; TGEN), which included 31 SORL1 single nucleotide polymorphisms (SNPs), eight of which overlapped the original study. Six SNPs, near the 3' region of SORL1 containing SNPs which were strongly associated with AD in previous studies, showed significant association in the TGEN dataset. These results provide an independent replication of the association between AD and SORL1.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 18090307 PMCID： PMC2631643 DOI： 10.1097/WNR.0b013e3282f13e7a

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

5 in total

1. Haploview: analysis and visualization of LD and haplotype maps.

Authors: J C Barrett; B Fry; J Maller; M J Daly
Journal: Bioinformatics Date: 2004-08-05 Impact factor: 6.937

2. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

Authors: Ekaterina Rogaeva; Yan Meng; Joseph H Lee; Yongjun Gu; Toshitaka Kawarai; Fanggeng Zou; Taiichi Katayama; Clinton T Baldwin; Rong Cheng; Hiroshi Hasegawa; Fusheng Chen; Nobuto Shibata; Kathryn L Lunetta; Raphaelle Pardossi-Piquard; Christopher Bohm; Yosuke Wakutani; L Adrienne Cupples; Karen T Cuenco; Robert C Green; Lorenzo Pinessi; Innocenzo Rainero; Sandro Sorbi; Amalia Bruni; Ranjan Duara; Robert P Friedland; Rivka Inzelberg; Wolfgang Hampe; Hideaki Bujo; You-Qiang Song; Olav M Andersen; Thomas E Willnow; Neill Graff-Radford; Ronald C Petersen; Dennis Dickson; Sandy D Der; Paul E Fraser; Gerold Schmitt-Ulms; Steven Younkin; Richard Mayeux; Lindsay A Farrer; Peter St George-Hyslop
Journal: Nat Genet Date: 2007-01-14 Impact factor: 38.330

3. PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors: Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal: Am J Hum Genet Date: 2007-07-25 Impact factor: 11.025

4. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.

Authors: Joseph H Lee; Rong Cheng; Nicole Schupf; Jennifer Manly; Rafael Lantigua; Yaakov Stern; Ekaterina Rogaeva; Yosuke Wakutani; Lindsay Farrer; Peter St George-Hyslop; Richard Mayeux
Journal: Arch Neurol Date: 2007-04

5. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

Authors: Eric M Reiman; Jennifer A Webster; Amanda J Myers; John Hardy; Travis Dunckley; Victoria L Zismann; Keta D Joshipura; John V Pearson; Diane Hu-Lince; Matthew J Huentelman; David W Craig; Keith D Coon; Winnie S Liang; RiLee H Herbert; Thomas Beach; Kristen C Rohrer; Alice S Zhao; Doris Leung; Leslie Bryden; Lauren Marlowe; Mona Kaleem; Diego Mastroeni; Andrew Grover; Christopher B Heward; Rivka Ravid; Joseph Rogers; Michael L Hutton; Stacey Melquist; Ron C Petersen; Gene E Alexander; Richard J Caselli; Walter Kukull; Andreas Papassotiropoulos; Dietrich A Stephan
Journal: Neuron Date: 2007-06-07 Impact factor: 17.173

5 in total

51 in total

Review 1. Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations.

Authors: Christiane Reitz
Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472

2. SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer’s disease.

Authors: Liang-Hao Guo; Christine Westerteicher; Xin-Hui Wang; Martina Kratzer; Amalia Tsolakidou; Meizi Jiang; Timo Grimmer; Simon M Laws; Panagiotis Alexopoulos; Hideaki Bujo; Alexander Kurz; Robert Perneczky
Journal: Eur Arch Psychiatry Clin Neurosci Date: 2012-09 Impact factor: 5.270

Association between SORL1 and Alzheimer's disease in a genome-wide study.

1. Haploview: analysis and visualization of LD and haplotype maps.

2. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

3. PLINK: a tool set for whole-genome association and population-based linkage analyses.

4. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.

5. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

Review 1. Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations.

2. SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer’s disease.

3. The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.

Review 4. Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease.

Review 5. The genetics and neuropathology of Alzheimer's disease.

Review 6. Dyslipidemia and the risk of Alzheimer's disease.

7. No association of SORL1 SNPs with Alzheimer's disease.

Review 8. Use of genetic variation as biomarkers for Alzheimer's disease.

9. Possible association between SORL1 and Alzheimer disease? Reanalysing the data of Shibata et al.

10. Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.