Literature DB >> 18087759

Towards understanding the immune system.

A H Hashish1, E Ahmed.   

Abstract

It is proposed that using both self-non-self and danger theories give a better understanding of how the immune system works. It is proposed that comparing the immune system to the police force is useful in this case since the police respond both to danger or damage signals and foreign or suspicious behavior even if no danger signals existed. We also propose that due to low zone tolerance, immunotherapy needs to be combined with another treatment method for cancer, e.g., chemotherapy or/and radiotherapy, to get sufficient eradication of tumors. Finally, we propose that fractional order differential equations are more suitable than the familiar integer order differential equations. A fractional order example of two immune effectors attacking an antigen is given.

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Year:  2007        PMID: 18087759     DOI: 10.1007/s12064-007-0011-y

Source DB:  PubMed          Journal:  Theory Biosci        ISSN: 1431-7613            Impact factor:   1.919


  5 in total

1.  Memory effects and macroscopic manifestation of randomness.

Authors:  A A Stanislavsky
Journal:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics       Date:  2000-05

2.  The danger model: a renewed sense of self.

Authors:  Polly Matzinger
Journal:  Science       Date:  2002-04-12       Impact factor: 47.728

3.  On modelling the immune system as a complex system.

Authors:  E Ahmed; A H Hashish
Journal:  Theory Biosci       Date:  2005-08-29       Impact factor: 1.919

Review 4.  The immune system evolved to discriminate infectious nonself from noninfectious self.

Authors:  C A Janeway
Journal:  Immunol Today       Date:  1992-01

Review 5.  An innate sense of danger.

Authors:  P Matzinger
Journal:  Semin Immunol       Date:  1998-10       Impact factor: 11.130

  5 in total
  1 in total

1.  Paradox of enrichment: A fractional differential approach with memory.

Authors:  Sourav Rana; Sabyasachi Bhattacharya; Joydeep Pal; Gaston M N'Guérékata; Joydev Chattopadhyay
Journal:  Physica A       Date:  2013-04-10       Impact factor: 3.263

  1 in total

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