Literature DB >> 17046369

On modelling the immune system as a complex system.

E Ahmed1, A H Hashish.   

Abstract

We argued that immune system is an adaptive complex system. It is shown that it has emergent properties. Its network structure is of the small world network type. The network is of the threshold type, which helps in avoiding autoimmunity. It has the property that every antigen (e.g. virus or bacteria) is typically attacked by more than one effector. This stabilizes the equilibrium state. Modelling complex systems is discussed. Cellular automata (CA)-type models are successful, but there are much less analytic results about CA than about other less successful models e.g. partial differential equations (PDE). A compromise is proposed.

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Year:  2005        PMID: 17046369     DOI: 10.1016/j.thbio.2005.07.001

Source DB:  PubMed          Journal:  Theory Biosci        ISSN: 1431-7613            Impact factor:   1.919


  2 in total

1.  Proliferation and competition in discrete biological systems.

Authors:  Yoram Louzoun; Sorin Solomon; Henri Atlan; Irun R Cohen
Journal:  Bull Math Biol       Date:  2003-05       Impact factor: 1.758

2.  Collective dynamics of 'small-world' networks.

Authors:  D J Watts; S H Strogatz
Journal:  Nature       Date:  1998-06-04       Impact factor: 49.962

  2 in total
  10 in total

1.  On managing complex adaptive systems motivated by biosystems application to infections.

Authors:  As Hegazi; Ah Hashish; E Ahmed
Journal:  Nonlinear Biomed Phys       Date:  2009-10-12

2.  On fractional order models for Hepatitis C.

Authors:  E Ahmed; H A El-Saka
Journal:  Nonlinear Biomed Phys       Date:  2010-03-18

3.  Towards understanding the immune system.

Authors:  A H Hashish; E Ahmed
Journal:  Theory Biosci       Date:  2007-07-19       Impact factor: 1.919

4.  On multi-strain model for Hepatitis C.

Authors:  E Ahmed; Ha El-Saka
Journal:  Nonlinear Biomed Phys       Date:  2011-08-03

5.  Systems Medicine-Complexity Within, Simplicity Without.

Authors:  Richard Berlin; Russell Gruen; James Best
Journal:  J Healthc Inform Res       Date:  2017-05-10

6.  ANIMA: Association network integration for multiscale analysis.

Authors:  Armin Deffur; Robert J Wilkinson; Bongani M Mayosi; Nicola M Mulder
Journal:  Wellcome Open Res       Date:  2018-11-14

7.  Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Authors:  Keertan Dheda; Laura Lenders; Shashikant Srivastava; Gesham Magombedze; Helen Wainwright; Prithvi Raj; Stephen J Bush; Gabriele Pollara; Rachelle Steyn; Malika Davids; Anil Pooran; Timothy Pennel; Anthony Linegar; Ruth McNerney; Loven Moodley; Jotam G Pasipanodya; Carolin T Turner; Mahdad Noursadeghi; Robin M Warren; Edward Wakeland; Tawanda Gumbo
Journal:  Am J Respir Crit Care Med       Date:  2019-08-01       Impact factor: 21.405

8.  Systematic characterization of human response to H1N1 influenza vaccination through the construction and integration of personalized transcriptome response profiles.

Authors:  Carlo De Intinis; Margherita Bodini; Denise Maffione; Laurane De Mot; Margherita Coccia; Duccio Medini; Emilio Siena
Journal:  Sci Rep       Date:  2021-10-21       Impact factor: 4.379

9.  Comments on introducing the immune system.

Authors:  E Ahmed
Journal:  Nonlinear Biomed Phys       Date:  2009-06-11

Review 10.  Towards the First Principles in Biology and Cancer: New Vistas in Computational Systems Biology of Cancer.

Authors:  Aleš Prokop
Journal:  Life (Basel)       Date:  2021-12-23
  10 in total

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