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Literature DB >> 18086838

Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin.

Jason M Cota¹, Jodi L Grabinski, Robert L Talbert, David S Burgess, P David Rogers, Thomas D Edlind, Nathan P Wiederhold.

Abstract

Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

Entities: Chemical Gene Species

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Year: 2007 PMID： 18086838 PMCID： PMC2258485 DOI： 10.1128/AAC.01542-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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6. Assessment of caspofungin susceptibility of Candida glabrata by the Etest®, CLSI, and EUCAST methods, and detection of FKS1 and FKS2 mutations.

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