Literature DB >> 18084304

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.

Margarita Malakhova1, Valentina Tereshko, Sung-Young Lee, Ke Yao, Yong-Yeon Cho, Ann Bode, Zigang Dong.   

Abstract

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

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Year:  2007        PMID： 18084304      PMCID： PMC2864125          DOI： 10.1038/nsmb1347

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  14 in total

1.  Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.

Authors:  Carol A Chrestensen; Thomas W Sturgill
Journal:  J Biol Chem       Date:  2002-05-16       Impact factor: 5.157

Review 2.  The conformational plasticity of protein kinases.

Authors:  Morgan Huse; John Kuriyan
Journal:  Cell       Date:  2002-05-03       Impact factor: 41.582

3.  A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

Authors:  S W Jones; E Erikson; J Blenis; J L Maller; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

4.  Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.

Authors:  J A Smith; C E Poteet-Smith; K Malarkey; T W Sturgill
Journal:  J Biol Chem       Date:  1999-01-29       Impact factor: 5.157

5.  Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

Authors:  T W Sturgill; L B Ray; E Erikson; J L Maller
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

6.  Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

Authors:  C E Poteet-Smith; J A Smith; D A Lannigan; T A Freed; T W Sturgill
Journal:  J Biol Chem       Date:  1999-08-06       Impact factor: 5.157

7.  Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.

Authors:  K N Dalby; N Morrice; F B Caudwell; J Avruch; P Cohen
Journal:  J Biol Chem       Date:  1998-01-16       Impact factor: 5.157

8.  Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.

Authors:  Philippe P Roux; Stephanie A Richards; John Blenis
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

9.  A protein kinase from Xenopus eggs specific for ribosomal protein S6.

Authors:  E Erikson; J L Maller
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

10.  Transcription factor phosphorylation by pp90(rsk2). Identification of Fos kinase and NGFI-B kinase I as pp90(rsk2).

Authors:  K D Swanson; L K Taylor; L Haung; A L Burlingame; G E Landreth
Journal:  J Biol Chem       Date:  1999-02-05       Impact factor: 5.157
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  21 in total

1.  Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1.

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Journal:  J Biol Chem       Date:  2009-10-05       Impact factor: 5.157

Review 2.  The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.

Authors:  Darkhan Utepbergenov; Zygmunt S Derewenda
Journal:  Biochim Biophys Acta       Date:  2013-03-27

3.  The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.

Authors:  Margarita Malakhova; Igor D'Angelo; Hong-Gyum Kim; Igor Kurinov; Ann M Bode; Zigang Dong
Journal:  J Mol Biol       Date:  2010-04-09       Impact factor: 5.469

Review 4.  Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.

Authors:  Gergő Gógl; Alexandr P Kornev; Attila Reményi; Susan S Taylor
Journal:  Trends Biochem Sci       Date:  2019-01-02       Impact factor: 13.807

5.  Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.

Authors:  Anita Alexa; Gergő Gógl; Gábor Glatz; Ágnes Garai; András Zeke; János Varga; Erika Dudás; Norbert Jeszenői; Andrea Bodor; Csaba Hetényi; Attila Reményi
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-17       Impact factor: 11.205

Review 6.  Signal transduction and molecular targets of selected flavonoids.

Authors:  Ann M Bode; Zigang Dong
Journal:  Antioxid Redox Signal       Date:  2013-04-15       Impact factor: 8.401

7.  Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition.

Authors:  Jonathan R St-Germain; Paul Taylor; Jiefei Tong; Lily L Jin; Ana Nikolic; Ian I Stewart; Robert M Ewing; Moyez Dharsee; Zhihua Li; Suzanne Trudel; Michael F Moran
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-09       Impact factor: 11.205

8.  Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.

Authors:  Ágnes Garai; András Zeke; Gergő Gógl; Imre Törő; Ferenc Fördős; Hagen Blankenburg; Tünde Bárkai; János Varga; Anita Alexa; Dorothea Emig; Mario Albrecht; Attila Reményi
Journal:  Sci Signal       Date:  2012-10-09       Impact factor: 8.192

9.  Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.

Authors:  Sumin Kang; Shannon Elf; Shaozhong Dong; Taro Hitosugi; Katherine Lythgoe; Ailan Guo; Hong Ruan; Sagar Lonial; Hanna J Khoury; Ifor R Williams; Benjamin H Lee; Johannes L Roesel; Gerard Karsenty; André Hanauer; Jack Taunton; Titus J Boggon; Ting-Lei Gu; Jing Chen
Journal:  Mol Cell Biol       Date:  2009-02-17       Impact factor: 4.272

10.  Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.

Authors:  Margarita Malakhova; Igor Kurinov; Kangdong Liu; Duo Zheng; Igor D'Angelo; Jung-Hyun Shim; Valerie Steinman; Ann M Bode; Zigang Dong
Journal:  PLoS One       Date:  2009-11-30       Impact factor: 3.240
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